Seroatlas · Human Serome Atlas

IPPK

Inositol-pentakisphosphate 2-kinase

Also known as: C9orf12, FLJ13163, INSP5K2, IP5K, IPK1, IPPK_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H8X2
Gene: IPPK
Ensembl: ENSG00000127080
Chromosome: 9
Canonical length: 491 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a kinase that phosphorylates position 2 of inositol-1,3,4,5,6-pentakisphosphate to form inositol-1,2,3,4,5,6-hexakisphosphate (InsP6). InsP6 has a variety of functions, including stimulation of DNA repair, endocytosis, and mRNA export. [provided by RefSeq, Nov 2010]

Canonical amino-acid sequenceUniProt

491 residues, UniProt reviewed canonical sequence.

>Q9H8X2|IPPK
     1  MEEGKMDENE WGYHGEGNKS LVVAHAQRCV VLRFLKFPPN RKKTSEEIFQ HLQNIVDFGK
    61  NVMKEFLGEN YVHYGEVVQL PLEFVKQLCL KIQSERPESR CDKDLDTLSG YAMCLPNLTR
   121  LQTYRFAEHR PILCVEIKPK CGFIPFSSDV THEMKHKVCR YCMHQHLKVA TGKWKQISKY
   181  CPLDLYSGNK QRMHFALKSL LQEAQNNLKI FKNGELIYGC KDARSPVADW SELAHHLKPF
   241  FFPSNGLASG PHCTRAVIRE LVHVITRVLL SGSDKGRAGT LSPGLGPQGP RVCEASPFSR
   301  SLRCQGKNTP ERSGLPKGCL LYKTLQVQML DLLDIEGLYP LYNRVERYLE EFPEERKTLQ
   361  IDGPYDEAFY QKLLDLSTED DGTVAFALTK VQQYRVAMTA KDCSIMIALS PCLQDASSDQ
   421  RPVVPSSRSR FAFSVSVLDL DLKPYESIPH QYKLDGKIVN YYSKTVRAKD NAVMSTRFKE
   481  SEDCTLVLHK V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IPPK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

esophagus: 31 nTPM
skin: 29 nTPM
vagina: 15 nTPM
cervix: 13 nTPM
cerebellum: 12 nTPM
testis: 11 nTPM

Single-cell type

esophageal apical cells: 208 nCPM
esophageal suprabasal cells: 163 nCPM
suprabasal keratinocytes: 139 nCPM
esophageal basal cells: 90 nCPM
basal keratinocytes: 89 nCPM
ocular epithelial cells: 65 nCPM

Immune cell

T-reg: 4.6 nTPM
MAIT T-cell: 4.2 nTPM
gdT-cell: 3.6 nTPM
eosinophil: 3.4 nTPM
memory CD8 T-cell: 3.1 nTPM
memory CD4 T-cell: 3 nTPM

Brain region

cerebellum: 18 nTPM
hippocampal formation: 17 nTPM
cerebral cortex: 16 nTPM
thalamus: 15 nTPM
pons: 14 nTPM
basal ganglia: 14 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IPPK.

Disease | ImmuneIEDB

Conditions an epitope on IPPK was assayed in.

hepatocellular carcinoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.37
gnomAD pLI: 0.87
gnomAD missense Z: 2
DepMap mean gene effect: -0.42
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ATP binding
molecular adaptor activity
inositol-1,3,4,5,6-pentakisphosphate 2-kinase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Inositol-pentakisphosphate 2-kinase
Inositol-pentakisphosphate 2-kinase, N-terminal lobe
Inositol-pentakisphosphate 2-kinase

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IPPK as an antibody target. Whether an autoantibody or antibody against IPPK could matter depends on whether native IPPK is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IPPK is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IPPK as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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