IPMK

Protein identityUniProt · HPA

UniProt accession

Q8NFU5

Gene

IPMK

Ensembl

ENSG00000151151

Chromosome

10

Canonical length

416 aa

Protein class

Enzymes, Metabolic proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Basal body

OverviewNCBI Gene

This gene encodes a member of the inositol phosphokinase family. The encoded protein has 3-kinase, 5-kinase and 6-kinase activities on phosphorylated inositol substrates. The encoded protein plays an important role in the biosynthesis of inositol 1,3,4,5,6-pentakisphosphate, and has a preferred 5-kinase activity. This gene may play a role in nuclear mRNA export. Pseudogenes of this gene are located on the long arm of chromosome 13 and the short arm of chromosome 19. [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

416 residues, UniProt reviewed canonical sequence.

>Q8NFU5|IPMK
     1  MATEPPSPLR VEAPGPPEMR TSPAIESTPE GTPQPAGGRL RFLNGCVPLS HQVAGHMYGK
    61  DKVGILQHPD GTVLKQLQPP PRGPRELEFY NMVYAADCFD GVLLELRKYL PKYYGIWSPP
   121  TAPNDLYLKL EDVTHKFNKP CIMDVKIGQK SYDPFASSEK IQQQVSKYPL MEEIGFLVLG
   181  MRVYHVHSDS YETENQHYGR SLTKETIKDG VSRFFHNGYC LRKDAVAASI QKIEKILQWF
   241  ENQKQLNFYA SSLLFVYEGS SQPTTTKLND RTLAEKFLSK GQLSDTEVLE YNNNFHVLSS
   301  TANGKIESSV GKSLSKMYAR HRKIYTKKHH SQTSLKVENL EQDNGWKSMS QEHLNGNVLS
   361  QLEKVFYHLP TGCQEIAEVE VRMIDFAHVF PSNTIDEGYV YGLKHLISVL RSILDN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IPMK can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.39

Highest tissue expression

17 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.33

gnomAD pLI

0.96

gnomAD missense Z

0.77

DepMap mean gene effect

-0.18

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• inositol phosphate biosynthetic process
• inositol phosphate metabolic process
• inositol trisphosphate metabolic process
• necroptotic process
• phosphatidylinositol metabolic process

Molecular functions

• 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity
• ATP binding
• flavonoid binding
• inositol-1,3,4,5-tetrakisphosphate 6-kinase activity
• inositol-1,4,5-trisphosphate 3-kinase activity
• metal ion binding
• inositol tetrakisphosphate kinase activity
• inositol-1,3,4,6-tetrakisphosphate 5-kinase activity
• inositol-1,4,5,6-tetrakisphosphate 3-kinase activity
• inositol-1,4,5-trisphosphate 6-kinase activity

Cellular components

• ciliary basal body
• cytoplasm
• nucleoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Inositol polyphosphate kinase
• Inositol polyphosphate kinase superfamily
• Inositol polyphosphate kinase

KeywordsUniProt

• Acetylation
• ATP-binding
• Kinase
• Lipid metabolism
• Magnesium
• Metal-binding
• Nucleotide-binding
• Nucleus
• Phospholipid metabolism
• Phosphoprotein
• Transferase