IP6K3

Protein identityUniProt · HPA

UniProt accession

Q96PC2

Gene

IP6K3

Ensembl

ENSG00000161896

Chromosome

6

Canonical length

410 aa

Protein class

Enzymes, Metabolic proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Dec 2008]

Canonical amino-acid sequenceUniProt

410 residues, UniProt reviewed canonical sequence.

>Q96PC2|IP6K3
     1  MVVQNSADAG DMRAGVQLEP FLHQVGGHMS VMKYDEHTVC KPLVSREQRF YESLPLAMKR
    61  FTPQYKGTVT VHLWKDSTGH LSLVANPVKE SQEPFKVSTE SAAVAIWQTL QQTTGSNGSD
   121  CTLAQWPHAQ LARSPKESPA KALLRSEPHL NTPAFSLVED TNGNQVERKS FNPWGLQCHQ
   181  AHLTRLCSEY PENKRHRFLL LENVVSQYTH PCVLDLKMGT RQHGDDASEE KKARHMRKCA
   241  QSTSACLGVR ICGMQVYQTD KKYFLCKDKY YGRKLSVEGF RQALYQFLHN GSHLRRELLE
   301  PILHQLRALL SVIRSQSSYR FYSSSLLVIY DGQEPPERAP GSPHPHEAPQ AAHGSSPGGL
   361  TKVDIRMIDF AHTTYKGYWN EHTTYDGPDP GYIFGLENLI RILQDIQEGE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IP6K3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.34

Highest tissue expression

291 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.22

gnomAD pLI

0

gnomAD missense Z

0.34

DepMap mean gene effect

-0.1

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• inositol phosphate biosynthetic process
• inositol phosphate metabolic process
• locomotion
• phosphatidylinositol metabolic process
• phosphatidylinositol phosphate biosynthetic process
• protein phosphorylation

Molecular functions

• ATP binding
• diphosphoinositol pentakisphosphate kinase activity
• diphosphoinositol tetrakisphosphate kinase activity
• inositol 5-diphosphate pentakisphosphate 5-kinase activity
• inositol hexakisphosphate 5-kinase activity
• inositol hexakisphosphate kinase activity
• inositol-1,3,4,5,6-pentakisphosphate kinase activity
• inositol hexakisphosphate 6-kinase activity

Cellular components

• cytoplasm
• cytosol
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Inositol polyphosphate kinase
• Inositol polyphosphate kinase superfamily
• Inositol polyphosphate kinase

KeywordsUniProt

• ATP-binding
• Cytoplasm
• Kinase
• Nucleotide-binding
• Transferase