Seroatlas · Human Serome Atlas

INTS15

Integrator complex subunit 15

Also known as: C7orf26, INT15_HUMAN, MGC2718

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96N11
Gene: INTS15
Ensembl: ENSG00000146576
Chromosome: 7
Canonical length: 449 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Mitotic spindle,Cytosol

OverviewNCBI Gene

Predicted to act upstream of or within brain development; eye development; and mRNA splicing, via spliceosome. Part of integrator complex. Is active in nucleus. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

449 residues, UniProt reviewed canonical sequence.

>Q96N11|INTS15
     1  MSDIRHSLLR RDALSAAKEV LYHLDIYFSS QLQSAPLPIV DKGPVELLEE FVFQVPKERS
    61  AQPKRLNSLQ ELQLLEIMCN YFQEQTKDSV RQIIFSSLFS PQGNKADDSR MSLLGKLVSM
   121  AVAVCRIPVL ECAASWLQRT PVVYCVRLAK ALVDDYCCLV PGSIQTLKQI FSASPRFCCQ
   181  FITSVTALYD LSSDDLIPPM DLLEMIVTWI FEDPRLILIT FLNTPIAANL PIGFLELTPL
   241  VGLIRWCVKA PLAYKRKKKP PLSNGHVSNK VTKDPGVGMD RDSHLLYSKL HLSVLQVLMT
   301  LQLHLTEKNL YGRLGLILFD HMVPLVEEIN RLADELNPLN ASQEIELSLD RLAQALQVAM
   361  ASGALLCTRD DLRTLCSRLP HNNLLQLVIS GPVQQSPHAA LPPGFYPHIH TPPLGYGAVP
   421  AHPAAHPALP THPGHTFISG VTFPFRPIR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against INTS15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

spleen: 26 nTPM
cervix: 23 nTPM
endometrium: 22 nTPM
prostate: 22 nTPM
fallopian tube: 21 nTPM
skeletal muscle: 21 nTPM

Single-cell type

respiratory ionocytes: 25 nCPM
epididymal clear cells: 23 nCPM
oligodendrocytes: 21 nCPM
erythrocyte progenitors: 21 nCPM
paneth cells: 19 nCPM
breast lactating cells: 19 nCPM

Immune cell

plasmacytoid DC: 2.9 nTPM
T-reg: 2.7 nTPM
MAIT T-cell: 2.6 nTPM
memory CD8 T-cell: 2.6 nTPM
memory CD4 T-cell: 2.4 nTPM
naive CD4 T-cell: 2.4 nTPM

Brain region

white matter: 30 nTPM
medulla oblongata: 28 nTPM
basal ganglia: 26 nTPM
cerebral cortex: 26 nTPM
thalamus: 25 nTPM
midbrain: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.3
gnomAD pLI: 0.98
DepMap mean gene effect: -0.35
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Integrator complex subunit 15
Integrator complex subunit 15

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads INTS15 as an antibody target. Whether an autoantibody or antibody against INTS15 could matter depends on whether native INTS15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

INTS15 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label INTS15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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