Seroatlas · Human Serome Atlas

INSYN2B

Protein INSYN2B

Also known as: C5orf57, FAM196B, INY2B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NMK8
Gene: INSYN2B
Ensembl: ENSG00000204767
Chromosome: 5
Canonical length: 535 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for INSYN2B in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

535 residues, UniProt reviewed canonical sequence.

>A6NMK8|INSYN2B
     1  MAQQNMKVRP VLLKRNSLES VEFVKQPHHR RSKSQQVRFK EDGTTKNPTG LAEVDVQTPE
    61  DPAVMGKTQA TRHHLPPTYS LSFPRSQKAG GFRNIAIQTS PSLRKHFPVF KRKRLTASKS
   121  LVEMPTASQS AIQVNGNLSE QDIVSSDLAY LRLAQHLEDG PRRVKVSHAF LPRVPKVQSN
   181  GPVSICLEAG TWRSLEKATA AIQVPDDIYH SPSWEARESA LSPDRSAEVS NSIHPLDDTR
   241  PGDGRRVTPL DSEKSTSCLN ATSVASHTPG TEELKPELLL PKDNSDDKDL GSLSSQSKET
   301  CVPSSPRTHS SPSQGSHSQP AHPGRASDCP SSSNNHQNLV SLKTNSASKS APGCQEQTAN
   361  NPTESDTLEF PNCPGSNHLP SSLSRSETKL QSNREISDIN QIHLARGELC DLQGRLQSVE
   421  ESLHSNQEKI KVLLNVIQDL EKARALTEGR NFYRTGQDLN NCSTCQNTAC IIYSVEYDFR
   481  QQEGRFHEVL QSLEEAEPVE EASPPPKSPA EPPAPEKQDL RRKTKKVKKK CFWWI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against INSYN2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.69
Highest tissue expression: 6.4 nTPM

Expression across tissuesHPA

Tissue

breast: 6.4 nTPM
salivary gland: 4.9 nTPM
cerebral cortex: 4.1 nTPM
hippocampal formation: 2.8 nTPM
midbrain: 2.5 nTPM
basal ganglia: 2.4 nTPM

Single-cell type

retinal pigment epithelial cells: 196 nCPM
oligodendrocytes: 143 nCPM
cdc: 88 nCPM
macrophages: 67 nCPM
microglia: 63 nCPM
medullary thymic epithelial cells: 58 nCPM

Immune cell

neutrophil: 0.3 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

basal ganglia: 13 nTPM
midbrain: 12 nTPM
white matter: 12 nTPM
thalamus: 11 nTPM
medulla oblongata: 11 nTPM
cerebral cortex: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.28
gnomAD pLI: 0.98
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Coiled coil

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads INSYN2B as an antibody target. Whether an autoantibody or antibody against INSYN2B could matter depends on whether native INSYN2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

INSYN2B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label INSYN2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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