INSYN2A
Inhibitory synaptic factor 2A
Also known as: C10orf141, FAM196A, FLJ45557, INSY2_HUMAN, INSYN2
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6ZSG2
- Gene
- INSYN2A
- Ensembl
- ENSG00000188916
- Chromosome
- 10
- Canonical length
- 479 aa
- Protein class
- Predicted intracellular proteins
OverviewNCBI Gene
Predicted to be involved in inhibitory postsynaptic potential. Predicted to be located in synapse. Predicted to be active in GABA-ergic synapse and postsynaptic density. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
479 residues, UniProt reviewed canonical sequence.
>Q6ZSG2|INSYN2A
1 MVSKDTGKCI LTTSESEVEP AACLALEMKY ALDPNRQIKK RNKALQVRFK DICEAQNEQR
61 DTQLSSGQLG EKREAKPVSC RAAYRKYMTV PARRSIPNVT KSTGVQTSPD LKKCYQTFPL
121 DRKKGNLKSL PAADPFKSQN NGFLTDAKEK NEAGPMEEAR PCGAGRVHKT TALVFHSNQH
181 MNTVDQPLGV NCTEPCKSPE PLSYGEAALQ NSTRPPSEEP DYQLLGRAKQ DRGRPNSEEP
241 APPALRRVFK TEVATVYAPA LSARAPEPGL SDSAAASQWS LCPADDERRR ATHLNGLQAP
301 SETALACSPP MQCLSPECSE QPSQTHTPPG LGNQPSPTAV AAGEECQRIV PHTEVVDLKA
361 QLQMMENLIS SSQETIKVLL GVIQELEKGE AHREGLSYRT GQDTANCDTC RNSACIIYSV
421 ELDFKQQEDK LQPVLRKLHP IEETQVIPSP YSQETYSSTP KQKSKTESKK HGRWKLWFLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against INSYN2A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.67
- Highest tissue expression
- 3.5 nTPM
Expression across tissuesHPA
Tissue
- basal ganglia: 3.5 nTPM
- hypothalamus: 2.3 nTPM
- midbrain: 2.3 nTPM
- amygdala: 1.7 nTPM
- cerebral cortex: 1.7 nTPM
- hippocampal formation: 1.4 nTPM
Single-cell type
- epicardial cells: 234 nCPM
- peritubular myoid cells: 83 nCPM
- leydig cells: 83 nCPM
- cardiomyocytes: 80 nCPM
- fibro-adipogenic progenitors: 79 nCPM
- retinal bipolar cells: 67 nCPM
Immune cell
- plasmacytoid DC: 0.6 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
Brain region
- thalamus: 21 nTPM
- basal ganglia: 16 nTPM
- midbrain: 15 nTPM
- hypothalamus: 15 nTPM
- cerebral cortex: 15 nTPM
- amygdala: 13 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.38
- gnomAD pLI
- 0.91
- DepMap mean gene effect
- 0.02
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of INSYN2A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads INSYN2A as an antibody target. Whether an autoantibody or antibody against INSYN2A could matter depends on whether native INSYN2A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
INSYN2A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label INSYN2A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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