Seroatlas · Human Serome Atlas

INSL6

Insulin-like peptide INSL6

Also known as: INSL6_HUMAN, RIF1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y581
Gene: INSL6
Ensembl: ENSG00000120210
Chromosome: 9
Canonical length: 213 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

The protein encoded by this gene contains a classical signature of the insulin superfamily and is significantly similar to relaxin and relaxin-like factor. This gene is preferentially expressed in testis. Its expression in testis is restricted to interstitial cells surrounding seminiferous tubules, which suggests a role in sperm development and fertilization. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

213 residues, UniProt reviewed canonical sequence.

>Q9Y581|INSL6
     1  MPRLLRLSLL WLGLLLVRFS RELSDISSAR KLCGRYLVKE IEKLCGHANW SQFRFEEETP
    61  FSRLIAQASE KVEAYSPYQF ESPQTASPAR GRGTNPVSTS WEEAVNSWEM QSLPEYKDKK
   121  GYSPLGKTRE FSSSHNINVY IHENAKFQKK RRNKIKTLSN LFWGHHPQRK RRGYSEKCCL
   181  TGCTKEELSI ACLPYIDFKR LKEKRSSLVT KIY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against INSL6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 15 nTPM

Expression across tissuesHPA

Tissue

testis: 15 nTPM
retina: 6.1 nTPM
blood vessel: 1.5 nTPM
bone marrow: 1.4 nTPM
skin: 1 nTPM
spleen: 1 nTPM

Single-cell type

epicardial cells: 187 nCPM
cardiomyocytes: 186 nCPM
early spermatids: 142 nCPM
late primary spermatocytes: 136 nCPM
myonuclei: 83 nCPM
adipocytes: 72 nCPM

Immune cell

basophil: 0.3 nTPM
neutrophil: 0.2 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

cerebral cortex: 8.6 nTPM
cerebellum: 8.4 nTPM
hypothalamus: 8.3 nTPM
white matter: 8.2 nTPM
pons: 7.8 nTPM
medulla oblongata: 7.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.92
gnomAD pLI: 0
gnomAD missense Z: -2.45
DepMap mean gene effect: 0.18
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

hormone activity

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

Insulin-like
Insulin, conserved site
Insulin-like superfamily
Mammalian Reproductive Hormone Insulin-like
Insulin/IGF/Relaxin family
Insulin-like peptide 6

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads INSL6 as an antibody target. Whether an autoantibody or antibody against INSL6 could matter depends on whether native INSL6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

INSL6 is annotated as secreted, so native INSL6 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label INSL6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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