INSL5
Insulin-like peptide INSL5
Also known as: INSL5_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9Y5Q6
- Gene
- INSL5
- Ensembl
- ENSG00000172410
- Chromosome
- 1
- Canonical length
- 135 aa
- Protein class
- Predicted secreted proteins
- Secretome location
- Secreted to blood
OverviewNCBI Gene
The protein encoded by this gene contains a classical signature of the insulin superfamily and is highly similar to relaxin 3 (RLN3/INSL7). [provided by RefSeq, Jul 2008]
Canonical amino-acid sequenceUniProt
135 residues, UniProt reviewed canonical sequence.
>Q9Y5Q6|INSL5
1 MKGSIFTLFL FSVLFAISEV RSKESVRLCG LEYIRTVIYI CASSRWRRHQ EGIPQAQQAE
61 TGNSFQLPHK REFSEENPAQ NLPKVDASGE DRLWGGQMPT EELWKSKKHS VMSRQDLQTL
121 CCTDGCSMTD LSALCLocalizationUniProt · AlphaFold · HPA
Whether an antibody against INSL5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.56
- Highest tissue expression
- 115 nTPM
Expression across tissuesHPA
Tissue
- rectum: 115 nTPM
- colon: 68 nTPM
- choroid plexus: 1 nTPM
- hypothalamus: 0.5 nTPM
- basal ganglia: 0.4 nTPM
- hippocampal formation: 0.4 nTPM
Single-cell type
- neuroendocrine cells: 4,176 nCPM
- enteric transient amplifying cells: 9.1 nCPM
- colonocytes: 8.4 nCPM
- enteric stem cells: 7.1 nCPM
- ependymal cells: 3.6 nCPM
- goblet cells: 2.8 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- choroid plexus: 1 nTPM
- medulla oblongata: 0.9 nTPM
- midbrain: 0.6 nTPM
- spinal cord: 0.5 nTPM
- basal ganglia: 0.4 nTPM
- cerebral cortex: 0.4 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.78
- gnomAD pLI
- 0.14
- gnomAD missense Z
- -0.05
- DepMap mean gene effect
- -0.08
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads INSL5 as an antibody target. Whether an autoantibody or antibody against INSL5 could matter depends on whether native INSL5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
INSL5 is annotated as secreted, so native INSL5 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label INSL5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...