Seroatlas · Human Serome Atlas

INO80D

INO80 complex subunit D

Also known as: FLJ20309, IN80D_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q53TQ3
Gene: INO80D
Ensembl: ENSG00000114933
Chromosome: 2
Canonical length: 1027 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Involved in several processes, including chromatin remodeling; regulation of chromosome organization; and regulation of nucleobase-containing compound metabolic process. Part of Ino80 complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1027 residues, UniProt reviewed canonical sequence.

>Q53TQ3|INO80D
     1  MYEGKHIHFS EVDNKPLCSY SPKLCKQRRL NGYAFCIRHV LEDKTAPFKQ CEYVAKYNSQ
    61  RCTNPIPKSE DRRYCNSHLQ VLGFIPKKER KKKNDPIDEV KVRHQMDTMA FSLTVPTLAL
   121  KMPNGLDGMS LSPPGARVPL HYLETELEDP FAFNEEDDDL KKGATVRKKL QSKLAQNRQR
   181  QRETEILKVR QEHFSPPPAP SQQQPPQQHS HLSPLSTSLK PPAPPQGSVC KSPQPQNTSL
   241  PMQGVAPTTH TIAQARQLSH KRPLPLLPSS RAPTVDPPRT DRILMKATAF SPHFSCISRL
   301  QRLVKLCTQK HQLDTDLFPH LGLDWSEESG EEPEDSEQAS PYQVAWSIRE TLRYQRHASD
   361  DDDAESRSSR VTQLCTYFQQ KYKHLCRLER AESRQKKCRH TFRKALLQAA SKEPECTGQL
   421  IQELRRAACS RTSISRTKLR EVEPAACSGT VKGEQCANKA LPFTRHCFQH ILLNHSQQLF
   481  SSCTAKFADG QQCSVPVFDI THQTPLCEEH AKKMDNFLRG DNSRKVQHQQ QRKPRKKTKP
   541  PALTKKHKKK RRRGPRRPQK PIPPAVPQGN LSMPASVSLP VEASHIRSPS TPELSADELP
   601  DDIANEITDI PHDLELNQED FSDVLPRLPD DLQDFDFFEG KNGDLLPTTE EAEELERALQ
   661  AVTSLECLST IGVLAQSDGV PVQELSDRGI GVFSTGTGAS GIQSLSREVN TDLGELLNGR
   721  IVHDNFSSLE LDENLLRSAT LSNPPTPLAG QIQGQFSAPA NVGLTSATLI SQSALGERAF
   781  PGQFHGLHDG SHASQRPHPA QLLSKADDLI TSRQQYSSDH SHSSPHGSHY DSEHVPSPYS
   841  DHITSPHTTS YSGDNMAATF SAEMPIMAQH LLPTQLEVPL GGVVNPRTHW GNLPVNLGDP
   901  SPFSNLLGAD GHLLSTSLST PPTTSNSETT QPAFATVTPS SSSVLPGLPQ TSFSGMGPSA
   961  ELMASTSPKQ QLPQFSAAFG HQLSSHSGIP KDLQPSHSSI APPTGFTVTG ATATSTNNAS
  1021  SPFPSPN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against INO80D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 17 nTPM
skin: 5.7 nTPM
skeletal muscle: 5.3 nTPM
testis: 5.2 nTPM
ovary: 4.7 nTPM
retina: 4.7 nTPM

Single-cell type

proximal tubule cells: 140 nCPM
renal collecting duct intercalated cells: 139 nCPM
distal convoluted tubule cells: 127 nCPM
choroid plexus epithelial cells: 117 nCPM
renal connecting tubule cells: 116 nCPM
loop of henle epithelial cells: 104 nCPM

Immune cell

naive B-cell: 5.3 nTPM
neutrophil: 5.3 nTPM
plasmacytoid DC: 4.5 nTPM
memory B-cell: 4.2 nTPM
basophil: 4.1 nTPM
non-classical monocyte: 3.4 nTPM

Brain region

cerebellum: 26 nTPM
white matter: 21 nTPM
cerebral cortex: 19 nTPM
medulla oblongata: 19 nTPM
basal ganglia: 17 nTPM
thalamus: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.23
gnomAD pLI: 1
gnomAD missense Z: 2.74
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads INO80D as an antibody target. Whether an autoantibody or antibody against INO80D could matter depends on whether native INO80D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

INO80D is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label INO80D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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