Seroatlas · Human Serome Atlas

INMT

Indolethylamine N-methyltransferase

Also known as: INMT_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95050
Gene: INMT
Ensembl: ENSG00000241644
Chromosome: 7
Canonical length: 263 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Golgi apparatus,Vesicles

OverviewNCBI Gene

N-methylation of endogenous and xenobiotic compounds is a major method by which they are degraded. This gene encodes an enzyme that N-methylates indoles such as tryptamine. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream MINDY4 (aka FAM188B) gene. In rodents and other mammals such as cetartiodactyla this gene is in the opposite orientation compared to its orientation in human and other primates and this gene appears to have been lost in carnivora and chiroptera. [provided by RefSeq, Jul 2019]

Canonical amino-acid sequenceUniProt

263 residues, UniProt reviewed canonical sequence.

>O95050|INMT
     1  MKGGFTGGDE YQKHFLPRDY LATYYSFDGS PSPEAEMLKF NLECLHKTFG PGGLQGDTLI
    61  DIGSGPTIYQ VLAACDSFQD ITLSDFTDRN REELEKWLKK EPGAYDWTPA VKFACELEGN
   121  SGRWEEKEEK LRAAVKRVLK CDVHLGNPLA PAVLPLADCV LTLLAMECAC CSLDAYRAAL
   181  CNLASLLKPG GHLVTTVTLR LPSYMVGKRE FSCVALEKEE VEQAVLDAGF DIEQLLHSPQ
   241  SYSVTNAANN GVCFIVARKK PGP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against INMT can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 195 nTPM

Expression across tissuesHPA

Tissue

lung: 195 nTPM
blood vessel: 93 nTPM
heart muscle: 73 nTPM
adipose tissue: 61 nTPM
adrenal gland: 50 nTPM
seminal vesicle: 45 nTPM

Single-cell type

tuft cells: 12 nCPM
vascular endothelial cells: 8.1 nCPM
retinal horizontal cells: 8 nCPM
choroid plexus epithelial cells: 6.9 nCPM
early spermatids: 4.8 nCPM
epicardial cells: 4.5 nCPM

Immune cell

basophil: 1.4 nTPM
neutrophil: 0.8 nTPM
NK-cell: 0.5 nTPM
memory B-cell: 0.4 nTPM
naive B-cell: 0.4 nTPM
plasmacytoid DC: 0.3 nTPM

Brain region

white matter: 38 nTPM
cerebral cortex: 32 nTPM
choroid plexus: 26 nTPM
medulla oblongata: 25 nTPM
hypothalamus: 23 nTPM
cerebellum: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.65
gnomAD pLI: 0
gnomAD missense Z: -0.36
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

N-methyltransferase activity
amine N-methyltransferase activity
thioether S-methyltransferase activity

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads INMT as an antibody target. Whether an autoantibody or antibody against INMT could matter depends on whether native INMT is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

INMT is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label INMT as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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