Seroatlas · Human Serome Atlas

INKA2

PAK4-inhibitor INKA2

Also known as: C1orf183, FAM212B, FLJ31105, INKA2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NTI7
Gene: INKA2
Ensembl: ENSG00000197852
Chromosome: 1
Canonical length: 297 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Vesicles

OverviewNCBI Gene

Enables protein kinase binding activity. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

297 residues, UniProt reviewed canonical sequence.

>Q9NTI7|INKA2
     1  MTMESREMDC YLRRLKQELM SMKEVGDGLQ DQMNCMMGAL QELKLLQVQT ALEQLEISGG
    61  GPVPGSPEGP RTQCEHPCWE GGRGPARPTV CSPSSQPSLG SSTKFPSHRS VCGRDLAPLP
   121  RTQPHQSCAQ QGPERVEPDD WTSTLMSRGR NRQPLVLGDN VFADLVGNWL DLPELEKGGE
   181  KGETGGAREP KGEKGQPQEL GRRFALTANI FKKFLRSVRP DRDRLLKEKP GWVTPMVPES
   241  RTGRSQKVKK RSLSKGSGHF PFPGTGEHRR GENPPTSCPK ALEHSPSGFD INTAVWV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against INKA2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 13 nTPM
cerebral cortex: 13 nTPM
hippocampal formation: 12 nTPM
amygdala: 8.5 nTPM
tongue: 8.3 nTPM
skeletal muscle: 7.2 nTPM

Single-cell type

platelets: 320 nCPM
cardiomyocytes: 228 nCPM
neutrophils: 163 nCPM
epicardial cells: 121 nCPM
adipocytes: 84 nCPM
fibro-adipogenic progenitors: 68 nCPM

Immune cell

neutrophil: 26 nTPM
non-classical monocyte: 2 nTPM
classical monocyte: 1.8 nTPM
eosinophil: 1.5 nTPM
intermediate monocyte: 1.4 nTPM
myeloid DC: 1 nTPM

Brain region

hippocampal formation: 30 nTPM
cerebral cortex: 27 nTPM
basal ganglia: 22 nTPM
white matter: 19 nTPM
amygdala: 18 nTPM
cerebellum: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.97
gnomAD pLI: 0.01
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Nucleus

InteractionsUniProt · HPA

Protein binding partners of INKA2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PAK4

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads INKA2 as an antibody target. Whether an autoantibody or antibody against INKA2 could matter depends on whether native INKA2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

INKA2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label INKA2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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