Seroatlas · Human Serome Atlas

INKA1

PAK4-inhibitor INKA1

Also known as: INKA1_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96EL1
Gene: INKA1
Canonical length: 287 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for INKA1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

287 residues, UniProt reviewed canonical sequence.

>Q96EL1|INKA1
     1  MDMHSARLDS FLSQLRWELL CGRDTGSPSM PGPLQPTSQT GPDVQPSHQL RASGALEEDS
    61  VCCVEEEEEE EEEAVVTEDR DAALGGPREH ALDWDSGFSE VSGSTWREEE LPVSQRPAPS
   121  AQPLRRQCLS VSGLPMPSRA PVASVPPVHH PRPKSTPDAC LEHWQGLEAE DWTAALLNRG
   181  RSRQPLVLGD NCFADLVHNW MELPETGSEG GDGGGHRARA RPPQFLLGLS EQLRRRLARA
   241  RRTAMAGKRL SCPPRPEPEL PADVSRFAAL MSCRSRQPII CNDVSYL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against INKA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

skin: 23 nTPM
esophagus: 19 nTPM
skeletal muscle: 11 nTPM
vagina: 9.9 nTPM
cervix: 9.1 nTPM
blood vessel: 8.9 nTPM

Single-cell type

platelets: 259 nCPM
megakaryocytes: 148 nCPM
hofbauer cells: 125 nCPM
esophageal suprabasal cells: 59 nCPM
esophageal basal cells: 56 nCPM
megakaryocyte progenitors: 54 nCPM

Immune cell

memory B-cell: 66 nTPM
naive B-cell: 65 nTPM
basophil: 60 nTPM
eosinophil: 12 nTPM
plasmacytoid DC: 9.3 nTPM
non-classical monocyte: 8.5 nTPM

Brain region

white matter: 11 nTPM
thalamus: 9.9 nTPM
medulla oblongata: 9.2 nTPM
spinal cord: 8.6 nTPM
hypothalamus: 8.2 nTPM
pons: 8.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of INKA1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

PAK4

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads INKA1 as an antibody target. Whether an autoantibody or antibody against INKA1 could matter depends on whether native INKA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

INKA1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label INKA1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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