Seroatlas · Human Serome Atlas

INAFM2

Putative transmembrane protein INAFM2

Also known as: INAM2_HUMAN, LINC00984, OGU1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0DMQ5
Gene
INAFM2
Ensembl
ENSG00000259330
Chromosome
15
Canonical length
153 aa
Protein class
Predicted membrane proteins, Transporters

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

153 residues, UniProt reviewed canonical sequence.

>P0DMQ5|INAFM2
     1  MKERDAAPAE RGKPATYTGD KKAKMAAKTN KKWVRLATVF AYVLSVSLAA IVLAVYYSLI
    61  WQPVGAGTSG GAAGPPPGGS NATGPSGTSG AAAAGPNTTG SSRREAPRDV PPLQAARPAP
   121  PEPPADSPPA GPLERPRGPD EDEEETAAAP GSR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against INAFM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.69
Highest tissue expression
47 nTPM

Expression across tissuesHPA

Tissue

  • colon: 47 nTPM
  • blood vessel: 45 nTPM
  • heart muscle: 27 nTPM
  • stomach: 27 nTPM
  • fallopian tube: 25 nTPM
  • thyroid gland: 25 nTPM

Single-cell type

  • platelets: 385 nCPM
  • megakaryocytes: 93 nCPM
  • late primary spermatocytes: 69 nCPM
  • hofbauer cells: 36 nCPM
  • smooth muscle cells: 35 nCPM
  • megakaryocyte progenitors: 32 nCPM

Immune cell

  • eosinophil: 2.7 nTPM
  • intermediate monocyte: 1.1 nTPM
  • plasmacytoid DC: 1.1 nTPM
  • classical monocyte: 1 nTPM
  • non-classical monocyte: 1 nTPM
  • neutrophil: 0.7 nTPM

Brain region

  • white matter: 33 nTPM
  • medulla oblongata: 27 nTPM
  • cerebral cortex: 25 nTPM
  • hypothalamus: 25 nTPM
  • spinal cord: 25 nTPM
  • basal ganglia: 23 nTPM

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads INAFM2 as an antibody target. Whether an autoantibody or antibody against INAFM2 could matter depends on whether native INAFM2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

INAFM2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label INAFM2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/INAFM2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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