Seroatlas · Human Serome Atlas

INAFM1

Putative transmembrane protein INAFM1

Also known as: INAM1_HUMAN, PRR24

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: C9JVW0
Gene: INAFM1
Ensembl: ENSG00000257704
Chromosome: 19
Canonical length: 142 aa
Protein class: Predicted intracellular proteins, Transporters

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

142 residues, UniProt reviewed canonical sequence.

>C9JVW0|INAFM1
     1  MRGTSCVGGG AESPGGAGLS EGPRGRWLRL APVCAYFLCV SLAAVLLAVY YGLIWVPTRS
    61  PAAPAGPQPS APSPPCAARP GVPPVPAPAA ASLSCLLGVP GGPRPQLQLP LSRRRRYSDP
   121  DRRPSRQTPR ETPEAAEGRR PG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against INAFM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 104 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 104 nTPM
blood vessel: 61 nTPM
cervix: 55 nTPM
colon: 54 nTPM
ovary: 53 nTPM
prostate: 51 nTPM

Single-cell type

decidual stromal cells: 77 nCPM
endometrial stromal cells: 67 nCPM
vascular smooth muscle cells: 65 nCPM
pericytes: 63 nCPM
hepatic stellate cells: 58 nCPM
leydig cells: 50 nCPM

Immune cell

neutrophil: 59 nTPM
eosinophil: 36 nTPM
plasmacytoid DC: 16 nTPM
classical monocyte: 16 nTPM
non-classical monocyte: 15 nTPM
myeloid DC: 14 nTPM

Brain region

hypothalamus: 63 nTPM
midbrain: 58 nTPM
medulla oblongata: 57 nTPM
choroid plexus: 52 nTPM
cerebral cortex: 49 nTPM
pons: 48 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.87
gnomAD pLI: 0.31
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads INAFM1 as an antibody target. Whether an autoantibody or antibody against INAFM1 could matter depends on whether native INAFM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

INAFM1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label INAFM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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