IMUP
Immortalization up-regulated protein
Also known as: C19orf33, H2RSP, IMUP_HUMAN, IMUP-1, IMUP-2
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9GZP8
- Gene
- IMUP
- Ensembl
- ENSG00000167644
- Chromosome
- 19
- Canonical length
- 106 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Plasma membrane,Cytosol
OverviewNCBI Gene
The protein encoded by this gene has been shown to be upregulated in SV40-immortalized fibroblasts as well as in endometrial carcinoma cells. The encoded protein is found primarily in the nucleus. This protein may play a role in placental development and diseases such as pre-eclampsia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Canonical amino-acid sequenceUniProt
106 residues, UniProt reviewed canonical sequence.
>Q9GZP8|IMUP
1 MEFDLGAALE PTSQKPGVGA GHGGDPKLSP HKVQGRSEAG AGPGPKQGHH SSSDSSSSSS
61 DSDTDVKSHA AGSKQHESIP GKAKKPKVKK KEKGKKEKGK KKEAPHLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IMUP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.74
- Highest tissue expression
- 689 nTPM
Expression across tissuesHPA
Tissue
- esophagus: 689 nTPM
- skin: 441 nTPM
- vagina: 294 nTPM
- cervix: 223 nTPM
- colon: 198 nTPM
- small intestine: 178 nTPM
Single-cell type
- colonocytes: 2,468 nCPM
- esophageal apical cells: 2,363 nCPM
- enterocytes: 1,592 nCPM
- esophageal suprabasal cells: 878 nCPM
- goblet cells: 851 nCPM
- foveolar cells: 752 nCPM
Immune cell
- myeloid DC: 22 nTPM
- total PBMC: 18 nTPM
- eosinophil: 2.3 nTPM
- basophil: 2.1 nTPM
- plasmacytoid DC: 1.8 nTPM
- naive B-cell: 1.4 nTPM
Brain region
- thalamus: 4 nTPM
- pons: 3.3 nTPM
- medulla oblongata: 2.6 nTPM
- basal ganglia: 2.5 nTPM
- midbrain: 2.4 nTPM
- cerebellum: 2.2 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.75
- gnomAD pLI
- 0.7
- DepMap mean gene effect
- 0.08
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Immortalization up-regulated protein
- Immortalisation up-regulated protein
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IMUP as an antibody target. Whether an autoantibody or antibody against IMUP could matter depends on whether native IMUP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IMUP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label IMUP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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