IL7

Protein identityUniProt · HPA

UniProt accession

P13232

Gene

IL7

Ensembl

ENSG00000104432

Chromosome

8

Canonical length

177 aa

Protein class

Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted secreted proteins

Secretome location

Secreted to blood

OverviewNCBI Gene

The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. IL7 is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. IL7 plays an essential role in lymphoid cell survival, and in the maintenance of naive and memory T cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can be a potent inducer of proinflammatory cytokines and chemokines which may defend against the infection, but may also mediate destructive lung injury. Elevated serum IL7 levels, together with several other circulating cytokines and chemokines, has been found to be associated with the severity of Coronavirus Disease 19 (COVID-19). [provided by RefSeq, Jul 2020]

Canonical amino-acid sequenceUniProt

177 residues, UniProt reviewed canonical sequence.

>P13232|IL7
     1  MFHVSFRYIF GLPPLILVLL PVASSDCDIE GKDGKQYESV LMVSIDQLLD SMKEIGSNCL
    61  NNEFNFFKRH ICDANKEGMF LFRAARKLRQ FLKMNSTGDF DLHLLKVSEG TTILLNCTGQ
   121  VKGRKPAALG EAQPTKSLEE NKSLKEQKKL NDLCFLKRLL QEIKTCWNKI LMGTKEH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IL7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.41

Highest tissue expression

8.3 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IL7.

Disease | AllUniProt

Conditions IL7 is implicated in, by any mechanism.

• Immunodeficiency 130 with HPV-related verrucosis (IMD130) MIM:618309

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 37 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Epidermodysplasia verruciformis, susceptibility to, 5

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.36

gnomAD pLI

0.93

gnomAD missense Z

0.7

DepMap mean gene effect

0.08

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• animal organ morphogenesis
• B cell proliferation
• bone resorption
• cell-cell signaling
• cytokine-mediated signaling pathway
• extrinsic apoptotic signaling pathway
• homeostasis of number of cells within a tissue
• humoral immune response
• interleukin-7-mediated signaling pathway
• negative regulation of apoptotic process
• negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
• organ growth
• positive regulation of B cell differentiation
• positive regulation of B cell proliferation
• positive regulation of cell population proliferation
• positive regulation of chemokine production
• positive regulation of cytokine-mediated signaling pathway
• positive regulation of organ growth
• positive regulation of T cell differentiation
• T cell lineage commitment

Molecular functions

• cytokine activity
• growth factor activity
• interleukin-7 receptor binding

Cellular components

• extracellular matrix
• extracellular region
• extracellular space

Protein domainsUniProt · Pfam · InterPro

• Interleukin-7/Interleukin-9, conserved site
• Interleukin-7
• Interleukin-7 superfamily
• Interleukin 7

KeywordsUniProt

• Cytokine
• Disulfide bond
• Glycoprotein
• Growth factor
• Secreted
• Signal

InteractionsUniProt · HPA

Protein binding partners of IL7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CSF2RG
• IL7R