Seroatlas · Human Serome Atlas

IL4I1

L-amino-acid oxidase

Also known as: FIG1, OXLA_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96RQ9
Gene: IL4I1
Ensembl: ENSG00000104951
Chromosome: 19
Canonical length: 567 aa
Protein class: Enzymes, Metabolic proteins, Predicted secreted proteins
Subcellular location: Acrosome
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene encodes a secreted L-amino acid oxidase protein which primarily catabolizes L-phenylalanine and, to a lesser extent, L-arginine. The expression of this gene is induced by the cytokine interleukin 4 in B cells. This gene is also expressed in macrophages and dendritic cells. This protein may play a role immune system escape as it is expressed in tumor-associated macrophages and suppresses T-cell responses. This protein also contains domains thought to be involved in the binding of flavin adenine dinucleotide (FAD) cofactor. Multiple transcript variants encoding different isoforms have been found for this gene. Some transcripts of this gene share a promoter and exons of the 5' UTR with the overlapping NUP62 gene. [provided by RefSeq, Jul 2020]

Canonical amino-acid sequenceUniProt

567 residues, UniProt reviewed canonical sequence.

>Q96RQ9|IL4I1
     1  MAPLALHLLV LVPILLSLVA SQDWKAERSQ DPFEKCMQDP DYEQLLKVVT WGLNRTLKPQ
    61  RVIVVGAGVA GLVAAKVLSD AGHKVTILEA DNRIGGRIFT YRDQNTGWIG ELGAMRMPSS
   121  HRILHKLCQG LGLNLTKFTQ YDKNTWTEVH EVKLRNYVVE KVPEKLGYAL RPQEKGHSPE
   181  DIYQMALNQA LKDLKALGCR KAMKKFERHT LLEYLLGEGN LSRPAVQLLG DVMSEDGFFY
   241  LSFAEALRAH SCLSDRLQYS RIVGGWDLLP RALLSSLSGL VLLNAPVVAM TQGPHDVHVQ
   301  IETSPPARNL KVLKADVVLL TASGPAVKRI TFSPPLPRHM QEALRRLHYV PATKVFLSFR
   361  RPFWREEHIE GGHSNTDRPS RMIFYPPPRE GALLLASYTW SDAAAAFAGL SREEALRLAL
   421  DDVAALHGPV VRQLWDGTGV VKRWAEDQHS QGGFVVQPPA LWQTEKDDWT VPYGRIYFAG
   481  EHTAYPHGWV ETAVKSALRA AIKINSRKGP ASDTASPEGH ASDMEGQGHV HGVASSPSHD
   541  LAKEEGSHPP VQGQLSLQNT THTRTSH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IL4I1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.29
Highest tissue expression: 28 nTPM

Expression across tissuesHPA

Tissue

testis: 28 nTPM
appendix: 17 nTPM
lymph node: 8.6 nTPM
tonsil: 6.2 nTPM
urinary bladder: 4.2 nTPM
bone marrow: 3.9 nTPM

Single-cell type

innate lymphoid cells: 379 nCPM
cdc: 244 nCPM
fallopian secretory cells: 140 nCPM
late primary spermatocytes: 124 nCPM
early spermatids: 67 nCPM
macrophages: 48 nCPM

Immune cell

MAIT T-cell: 104 nTPM
intermediate monocyte: 37 nTPM
classical monocyte: 22 nTPM
memory CD4 T-cell: 13 nTPM
memory CD8 T-cell: 12 nTPM
myeloid DC: 11 nTPM

Brain region

white matter: 4.6 nTPM
pons: 3.8 nTPM
medulla oblongata: 3.7 nTPM
thalamus: 2.8 nTPM
spinal cord: 2.3 nTPM
midbrain: 2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.89
gnomAD pLI: 0
gnomAD missense Z: 1.78
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

L-amino-acid oxidase activity
L-phenylalaine oxidase activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IL4I1 as an antibody target. Whether an autoantibody or antibody against IL4I1 could matter depends on whether native IL4I1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IL4I1 is annotated as secreted, so native IL4I1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label IL4I1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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