Seroatlas · Human Serome Atlas

IL36B

Interleukin-36 beta

Also known as: FIL1, FILI-(ETA), IL-1F8, IL-1H2, IL1-ETA, IL1F8, IL1H2, IL36B_HUMAN, MGC126880, MGC126882

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NZH7
Gene: IL36B
Ensembl: ENSG00000136696
Chromosome: 2
Canonical length: 164 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

The protein encoded by this gene is a member of the interleukin 1 cytokine family. Protein structure modeling indicated that this cytokine may contain a 12-stranded beta-trefoil structure that is conserved between IL1A (IL-A alpha) and IL1B (IL-1 beta). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

164 residues, UniProt reviewed canonical sequence.

>Q9NZH7|IL36B
     1  MNPQREAAPK SYAIRDSRQM VWVLSGNSLI AAPLSRSIKP VTLHLIACRD TEFSDKEKGN
    61  MVYLGIKGKD LCLFCAEIQG KPTLQLKLQG SQDNIGKDTC WKLVGIHTCI NLDVRESCFM
   121  GTLDQWGIGV GRKKWKSSFQ HHHLRKKDKD FSSMRTNIGM PGRM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IL36B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 8 nTPM

Expression across tissuesHPA

Tissue

skin: 8 nTPM
tonsil: 3.5 nTPM
esophagus: 2.1 nTPM
breast: 0.9 nTPM
cervix: 0.9 nTPM
salivary gland: 0.4 nTPM

Single-cell type

esophageal apical cells: 54 nCPM
esophageal suprabasal cells: 1.7 nCPM
suprabasal keratinocytes: 1.6 nCPM
ocular epithelial cells: 1.3 nCPM
lacrimal acinar cells: 0.9 nCPM
early primary spermatocytes: 0.7 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
cerebral cortex: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.2
gnomAD pLI: 0
gnomAD missense Z: -0.19
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IL36B as an antibody target. Whether an autoantibody or antibody against IL36B could matter depends on whether native IL36B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IL36B is annotated as secreted, so native IL36B circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label IL36B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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