Seroatlas · Human Serome Atlas

IL34

Interleukin-34

Also known as: C16orf77, IL-34, IL34_HUMAN, MGC34647

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZMJ4
Gene: IL34
Ensembl: ENSG00000157368
Chromosome: 16
Canonical length: 242 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted to blood
Quaternary structure: Homodimer

OverviewNCBI Gene

Interleukin-34 is a cytokine that promotes the differentiation and viability of monocytes and macrophages through the colony-stimulating factor-1 receptor (CSF1R; MIM 164770) (Lin et al., 2008 [PubMed 18467591]).[supplied by OMIM, May 2008]

Canonical amino-acid sequenceUniProt

242 residues, UniProt reviewed canonical sequence.

>Q6ZMJ4|IL34
     1  MPRGFTWLRY LGIFLGVALG NEPLEMWPLT QNEECTVTGF LRDKLQYRSR LQYMKHYFPI
    61  NYKISVPYEG VFRIANVTRL QRAQVSEREL RYLWVLVSLS ATESVQDVLL EGHPSWKYLQ
   121  EVETLLLNVQ QGLTDVEVSP KVESVLSLLN APGPNLKLVR PKALLDNCFR VMELLYCSCC
   181  KQSSVLNWQD CEVPSPQSCS PEPSLQYAAT QLYPPPPWSP SSPPHSTGSV RPVRAQGEGL
   241  LP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IL34 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 104 nTPM

Expression across tissuesHPA

Tissue

spleen: 104 nTPM
skin: 62 nTPM
choroid plexus: 32 nTPM
blood vessel: 26 nTPM
esophagus: 26 nTPM
adrenal gland: 24 nTPM

Single-cell type

esophageal apical cells: 230 nCPM
schwann cells: 117 nCPM
breast myoepithelial cells: 79 nCPM
breast secretory cells: 77 nCPM
lacrimal acinar cells: 75 nCPM
peritubular myoid cells: 63 nCPM

Immune cell

eosinophil: 19 nTPM
basophil: 1.4 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 39 nTPM
hippocampal formation: 38 nTPM
cerebral cortex: 31 nTPM
hypothalamus: 29 nTPM
basal ganglia: 27 nTPM
amygdala: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.57
gnomAD pLI: 0.55
gnomAD missense Z: -0.77
DepMap mean gene effect: -0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Interleukin-34
Interleukin-34 superfamily
Interleukin 34

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IL34 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CSF1R

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IL34 as an antibody target. Whether an autoantibody or antibody against IL34 could matter depends on whether native IL34 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IL34 is annotated as secreted, so native IL34 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label IL34 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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