Seroatlas · Human Serome Atlas

IL32

Interleukin-32

Also known as: IL32_HUMAN, NK4, TAIF, TAIFb, TAIFd

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P24001
Gene: IL32
Ensembl: ENSG00000008517
Chromosome: 16
Canonical length: 234 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene encodes a member of the cytokine family. The protein contains a tyrosine sulfation site, 3 potential N-myristoylation sites, multiple putative phosphorylation sites, and an RGD cell-attachment sequence. Expression of this protein is increased after the activation of T-cells by mitogens or the activation of NK cells by IL-2. This protein induces the production of TNFalpha from macrophage cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

234 residues, UniProt reviewed canonical sequence.

>P24001|IL32
     1  MCFPKVLSDD MKKLKARMVM LLPTSAQGLG AWVSACDTED TVGHLGPWRD KDPALWCQLC
    61  LSSQHQAIER FYDKMQNAES GRGQVMSSLA ELEDDFKEGY LETVAAYYEE QHPELTPLLE
   121  KERDGLRCRG NRSPVPDVED PATEEPGESF CDKVMRWFQA MLQRLQTWWH GVLAWVKEKV
   181  VALVHAVQAL WKQFQSFCCS LSELFMSSFQ SYGAPRGDKE ELTPQKCSEP QSSK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IL32 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 831 nTPM

Expression across tissuesHPA

Tissue

liver: 831 nTPM
pancreas: 686 nTPM
small intestine: 526 nTPM
skeletal muscle: 510 nTPM
spleen: 415 nTPM
kidney: 415 nTPM

Single-cell type

enterocytes: 4,883 nCPM
pancreatic acinar cells: 1,531 nCPM
colonocytes: 1,213 nCPM
t-cells: 984 nCPM
pancreatic duct cells: 848 nCPM
nk-cells: 571 nCPM

Immune cell

T-reg: 4,640 nTPM
MAIT T-cell: 2,590 nTPM
gdT-cell: 2,578 nTPM
memory CD8 T-cell: 2,483 nTPM
memory CD4 T-cell: 2,345 nTPM
total PBMC: 2,240 nTPM

Brain region

thalamus: 24 nTPM
medulla oblongata: 22 nTPM
pons: 20 nTPM
cerebral cortex: 18 nTPM
spinal cord: 16 nTPM
amygdala: 16 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IL32.

Disease | ImmuneIEDB

Conditions an epitope on IL32 was assayed in.

type 1 diabetes mellitus T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.92
gnomAD pLI: 0
gnomAD missense Z: -2.35
DepMap mean gene effect: 0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

cytokine activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Interleukin-32
Interleukin 32

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IL32 as an antibody target. Whether an autoantibody or antibody against IL32 could matter depends on whether native IL32 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IL32 is annotated as secreted, so native IL32 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label IL32 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...