IL31
Interleukin-31
Also known as: IL-31, IL31_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6EBC2
- Gene
- IL31
- Ensembl
- ENSG00000204671
- Chromosome
- 12
- Canonical length
- 164 aa
- Protein class
- Predicted secreted proteins
- Secretome location
- Secreted to blood
OverviewNCBI Gene
IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma (Dillon et al., 2004 [PubMed 15184896]).[supplied by OMIM, Mar 2008]
Canonical amino-acid sequenceUniProt
164 residues, UniProt reviewed canonical sequence.
>Q6EBC2|IL31
1 MASHSGPSTS VLFLFCCLGG WLASHTLPVR LLRPSDDVQK IVEELQSLSK MLLKDVEEEK
61 GVLVSQNYTL PCLSPDAQPP NNIHSPAIRA YLKTIRQLDN KSVIDEIIEH LDKLIFQDAP
121 ETNISVPTDT HECKRFILTI SQQFSECMDL ALKSLTSGAQ QATTLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IL31 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.4
- Highest tissue expression
- 0.1 nTPM
Expression across tissuesHPA
Tissue
- testis: 0.1 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
- basal ganglia: 0 nTPM
Single-cell type
- epicardial cells: 4.5 nCPM
- early spermatids: 1.3 nCPM
- late primary spermatocytes: 1 nCPM
- thymocytes: 0.8 nCPM
- endometrial luminal cells: 0.3 nCPM
- breast lactating cells: 0.2 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 0.6 nTPM
- pons: 0.5 nTPM
- medulla oblongata: 0.3 nTPM
- amygdala: 0.2 nTPM
- basal ganglia: 0.2 nTPM
- cerebellum: 0.2 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.72
- gnomAD pLI
- 0.01
- gnomAD missense Z
- 0.72
- DepMap mean gene effect
- -0.08
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Interleukin-31
- Interleukin 31
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IL31 as an antibody target. Whether an autoantibody or antibody against IL31 could matter depends on whether native IL31 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IL31 is annotated as secreted, so native IL31 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label IL31 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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