Seroatlas · Human Serome Atlas

IL27RA

Interleukin-27 receptor subunit alpha

Also known as: CRL1, I27RA_HUMAN, IL-27R, TCCR, WSX-1, WSX1, zcytor1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UWB1
Gene: IL27RA
Ensembl: ENSG00000104998
Chromosome: 19
Canonical length: 636 aa
Protein class: Predicted membrane proteins
Subcellular location: Vesicles

OverviewNCBI Gene

In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

636 residues, UniProt reviewed canonical sequence.

>Q6UWB1|IL27RA
     1  MRGGRGAPFW LWPLPKLALL PLLWVLFQRT RPQGSAGPLQ CYGVGPLGDL NCSWEPLGDL
    61  GAPSELHLQS QKYRSNKTQT VAVAAGRSWV AIPREQLTMS DKLLVWGTKA GQPLWPPVFV
   121  NLETQMKPNA PRLGPDVDFS EDDPLEATVH WAPPTWPSHK VLICQFHYRR CQEAAWTLLE
   181  PELKTIPLTP VEIQDLELAT GYKVYGRCRM EKEEDLWGEW SPILSFQTPP SAPKDVWVSG
   241  NLCGTPGGEE PLLLWKAPGP CVQVSYKVWF WVGGRELSPE GITCCCSLIP SGAEWARVSA
   301  VNATSWEPLT NLSLVCLDSA SAPRSVAVSS IAGSTELLVT WQPGPGEPLE HVVDWARDGD
   361  PLEKLNWVRL PPGNLSALLP GNFTVGVPYR ITVTAVSASG LASASSVWGF REELAPLVGP
   421  TLWRLQDAPP GTPAIAWGEV PRHQLRGHLT HYTLCAQSGT SPSVCMNVSG NTQSVTLPDL
   481  PWGPCELWVT ASTIAGQGPP GPILRLHLPD NTLRWKVLPG ILFLWGLFLL GCGLSLATSG
   541  RCYHLRHKVL PRWVWEKVPD PANSSSGQPH MEQVPEAQPL GDLPILEVEE MEPPPVMESS
   601  QPAQATAPLD SGYEKHFLPT PEELGLLGPP RPQVLA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IL27RA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

tonsil: 16 nTPM
spleen: 14 nTPM
lymph node: 12 nTPM
thymus: 10 nTPM
appendix: 8.2 nTPM
heart muscle: 7.6 nTPM

Single-cell type

tuft cells: 12 nCPM
ependymal cells: 8.1 nCPM
nk-cells: 8 nCPM
t-cells: 6.7 nCPM
brain excitatory neurons: 4.9 nCPM
other brain neurons: 4.9 nCPM

Immune cell

naive CD4 T-cell: 26 nTPM
gdT-cell: 24 nTPM
memory CD4 T-cell: 24 nTPM
T-reg: 23 nTPM
NK-cell: 23 nTPM
classical monocyte: 23 nTPM

Brain region

hypothalamus: 4.1 nTPM
hippocampal formation: 3.4 nTPM
pons: 3.3 nTPM
cerebral cortex: 3.2 nTPM
medulla oblongata: 3 nTPM
midbrain: 2.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.9
gnomAD pLI: 0
gnomAD missense Z: 1.12
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IL27RA as an antibody target. Whether an autoantibody or antibody against IL27RA could matter depends on whether native IL27RA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IL27RA is annotated at the cell surface, where native IL27RA is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Source-annotated serology context

The source annotations explicitly mention antibody, autoantibody, autoantigen, or autoimmune context. This is biological context, not study-specific reactivity.

Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses.

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