Seroatlas · Human Serome Atlas

IL25

Interleukin-25

Also known as: IL-17E, IL-25, IL17E, IL25_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H293
Gene: IL25
Ensembl: ENSG00000166090
Chromosome: 14
Canonical length: 177 aa
Protein class: Predicted intracellular proteins, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

The protein encoded by this gene is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. Studies of a similar gene in mice suggest that this cytokine may be a pro-inflammatory cytokine favoring the Th2-type immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

Canonical amino-acid sequenceUniProt

177 residues, UniProt reviewed canonical sequence.

>Q9H293|IL25
     1  MRERPRLGED SSLISLFLQV VAFLAMVMGT HTYSHWPSCC PSKGQDTSEE LLRWSTVPVP
    61  PLEPARPNRH PESCRASEDG PLNSRAISPW RYELDRDLNR LPQDLYHARC LCPHCVSLQT
   121  GSHMDPRGNS ELLYHNQTVF YRRPCHGEKG THKGYCLERR LYRVSLACVC VRPRVMG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IL25 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 0.5 nTPM

Expression across tissuesHPA

Tissue

testis: 0.5 nTPM
heart muscle: 0.4 nTPM
skeletal muscle: 0.2 nTPM
skin: 0.2 nTPM
basal ganglia: 0.1 nTPM
cerebral cortex: 0.1 nTPM

Single-cell type

late primary spermatocytes: 1.9 nCPM
cardiomyocytes: 0.9 nCPM
ependymal cells: 0.9 nCPM
epididymal basal cells: 0.8 nCPM
early spermatids: 0.5 nCPM
myonuclei: 0.4 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

midbrain: 0.3 nTPM
medulla oblongata: 0.2 nTPM
white matter: 0.2 nTPM
amygdala: 0.1 nTPM
basal ganglia: 0.1 nTPM
cerebellum: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.6
gnomAD pLI: 0
gnomAD missense Z: -0.01
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

cytokine activity
interleukin-17E receptor binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IL25 as an antibody target. Whether an autoantibody or antibody against IL25 could matter depends on whether native IL25 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IL25 is annotated as secreted, so native IL25 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label IL25 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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