Seroatlas · Human Serome Atlas

IL20RB

Interleukin-20 receptor subunit beta

Also known as: DIRS1, FNDC6, I20RB_HUMAN, IL-20R2, MGC34923

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UXL0
Gene: IL20RB
Ensembl: ENSG00000174564
Chromosome: 3
Canonical length: 311 aa
Protein class: Predicted membrane proteins
Subcellular location: Vesicles,Cytosol

OverviewNCBI Gene

IL20RB and IL20RA (MIM 605620) form a heterodimeric receptor for interleukin-20 (IL20; MIM 605619) (Blumberg et al., 2001 [PubMed 11163236]).[supplied by OMIM, Feb 2009]

Canonical amino-acid sequenceUniProt

311 residues, UniProt reviewed canonical sequence.

>Q6UXL0|IL20RB
     1  MQTFTMVLEE IWTSLFMWFF YALIPCLLTD EVAILPAPQN LSVLSTNMKH LLMWSPVIAP
    61  GETVYYSVEY QGEYESLYTS HIWIPSSWCS LTEGPECDVT DDITATVPYN LRVRATLGSQ
   121  TSAWSILKHP FNRNSTILTR PGMEITKDGF HLVIELEDLG PQFEFLVAYW RREPGAEEHV
   181  KMVRSGGIPV HLETMEPGAA YCVKAQTFVK AIGRYSAFSQ TECVEVQGEA IPLVLALFAF
   241  VGFMLILVVV PLFVWKMGRL LQYSCCPVVV LPDTLKITNS PQKLISCRRE EVDACATAVM
   301  SPEELLRAWI S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IL20RB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 166 nTPM

Expression across tissuesHPA

Tissue

skin: 166 nTPM
esophagus: 121 nTPM
vagina: 74 nTPM
cervix: 58 nTPM
salivary gland: 13 nTPM
breast: 9.6 nTPM

Single-cell type

esophageal apical cells: 547 nCPM
esophageal suprabasal cells: 273 nCPM
esophageal basal cells: 174 nCPM
suprabasal keratinocytes: 142 nCPM
basal keratinocytes: 102 nCPM
ocular epithelial cells: 88 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

thalamus: 0.2 nTPM
medulla oblongata: 0.1 nTPM
pons: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.3
gnomAD pLI: 0
gnomAD missense Z: 0.61
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IL20RB as an antibody target. Whether an autoantibody or antibody against IL20RB could matter depends on whether native IL20RB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IL20RB is annotated at the cell surface, where native IL20RB is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IL20RB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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