Seroatlas · Human Serome Atlas

IL20RA

Interleukin-20 receptor subunit alpha

Also known as: I20RA_HUMAN, IL-20R1, ZCYTOR7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UHF4
Gene
IL20RA
Ensembl
ENSG00000016402
Chromosome
6
Canonical length
553 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Cytosol

OverviewNCBI Gene

This gene encodes a member of the type II cytokine receptor family. The encoded protein is a subunit of the receptor for interleukin 20, a cytokine that may be involved in epidermal function. The interleukin 20 receptor is a heterodimeric complex consisting of the encoded protein and interleukin 20 receptor beta. This gene and interleukin 20 receptor beta are highly expressed in skin, and are upregulated in psoriasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

553 residues, UniProt reviewed canonical sequence.

>Q9UHF4|IL20RA
     1  MRAPGRPALR PLPLPPLLLL LLAAPWGRAV PCVSGGLPKP ANITFLSINM KNVLQWTPPE
    61  GLQGVKVTYT VQYFIYGQKK WLNKSECRNI NRTYCDLSAE TSDYEHQYYA KVKAIWGTKC
   121  SKWAESGRFY PFLETQIGPP EVALTTDEKS ISVVLTAPEK WKRNPEDLPV SMQQIYSNLK
   181  YNVSVLNTKS NRTWSQCVTN HTLVLTWLEP NTLYCVHVES FVPGPPRRAQ PSEKQCARTL
   241  KDQSSEFKAK IIFWYVLPVS ITVFLFSVMG YSIYRYIHVG KEKHPANLIL IYGNEFDKRF
   301  FVPAEKIVIN FITLNISDDS KISHQDMSLL GKSSDVSSLN DPQPSGNLRP PQEEEEVKHL
   361  GYASHLMEIF CDSEENTEGT SLTQQESLSR TIPPDKTVIE YEYDVRTTDI CAGPEEQELS
   421  LQEEVSTQGT LLESQAALAV LGPQTLQYSY TPQLQDLDPL AQEHTDSEEG PEEEPSTTLV
   481  DWDPQTGRLC IPSLSSFDQD SEGCEPSEGD GLGEEGLLSR LYEEPAPDRP PGENETYLMQ
   541  FMEEWGLYVQ MEN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IL20RA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
36 nTPM

Expression across tissuesHPA

Tissue

  • skin: 36 nTPM
  • breast: 25 nTPM
  • fallopian tube: 16 nTPM
  • cervix: 16 nTPM
  • vagina: 11 nTPM
  • salivary gland: 9.1 nTPM

Single-cell type

  • endometrial ciliated cells: 134 nCPM
  • respiratory ciliated cells: 112 nCPM
  • fallopian tube ciliated cells: 107 nCPM
  • endometrial luminal cells: 92 nCPM
  • alveolar cells type 2: 90 nCPM
  • neuroendocrine cells: 87 nCPM

Immune cell

  • memory CD4 T-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • choroid plexus: 7.1 nTPM
  • midbrain: 6.9 nTPM
  • spinal cord: 6.2 nTPM
  • thalamus: 6 nTPM
  • medulla oblongata: 5.6 nTPM
  • cerebellum: 5.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.64
gnomAD pLI
0.03
gnomAD missense Z
0.71
DepMap mean gene effect
0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IL20RA as an antibody target. Whether an autoantibody or antibody against IL20RA could matter depends on whether native IL20RA is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IL20RA is annotated at the cell surface, where native IL20RA is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IL20RA as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IL20RA. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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