Seroatlas · Human Serome Atlas

IL1RAPL2

X-linked interleukin-1 receptor accessory protein-like 2

Also known as: IL-1R9, IL1R9, IL1RAPL-2, IRPL2_HUMAN, TIGIRR-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NP60
Gene
IL1RAPL2
Ensembl
ENSG00000189108
Chromosome
X
Canonical length
686 aa
Protein class
Enzymes, Predicted membrane proteins
Subcellular location
Plasma membrane

OverviewNCBI Gene

The protein encoded by this gene is a member of the interleukin 1 receptor family. This protein is similar to the interleukin 1 accessory proteins, and is most closely related to interleukin 1 receptor accessory protein-like 1 (IL1RAPL1). This gene and IL1RAPL1 are located at a region on chromosome X that is associated with X-linked non-syndromic cognitive disability. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

686 residues, UniProt reviewed canonical sequence.

>Q9NP60|IL1RAPL2
     1  MKPPFLLALV VCSVVSTNLK MVSKRNSVDG CIDWSVDLKT YMALAGEPVR VKCALFYSYI
    61  RTNYSTAQST GLRLMWYKNK GDLEEPIIFS EVRMSKEEDS IWFHSAEAQD SGFYTCVLRN
   121  STYCMKVSMS LTVAENESGL CYNSRIRYLE KSEVTKRKEI SCPDMDDFKK SDQEPDVVWY
   181  KECKPKMWRS IIIQKGNALL IQEVQEEDGG NYTCELKYEG KLVRRTTELK VTALLTDKPP
   241  KPLFPMENQP SVIDVQLGKP LNIPCKAFFG FSGESGPMIY WMKGEKFIEE LAGHIREGEI
   301  RLLKEHLGEK EVELALIFDS VVEADLANYT CHVENRNGRK HASVLLRKKD LIYKIELAGG
   361  LGAIFLLLVL LVVIYKCYNI ELMLFYRQHF GADETNDDNK EYDAYLSYTK VDQDTLDCDN
   421  PEEEQFALEV LPDVLEKHYG YKLFIPERDL IPSGTYMEDL TRYVEQSRRL IIVLTPDYIL
   481  RRGWSIFELE SRLHNMLVSG EIKVILIECT ELKGKVNCQE VESLKRSIKL LSLIKWKGSK
   541  SSKLNSKFWK HLVYEMPIKK KEMLPRCHVL DSAEQGLFGE LQPIPSIAMT STSATLVSSQ
   601  ADLPEFHPSD SMQIRHCCRG YKHEIPATTL PVPSLGNHHT YCNLPLTLLN GQLPLNNTLK
   661  DTQEFHRNSS LLPLSSKELS FTSDIW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IL1RAPL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
1.3 nTPM

Expression across tissuesHPA

Tissue

  • adrenal gland: 1.3 nTPM
  • liver: 0.9 nTPM
  • parathyroid gland: 0.9 nTPM
  • testis: 0.6 nTPM
  • urinary bladder: 0.6 nTPM
  • breast: 0.4 nTPM

Single-cell type

  • leydig cells: 646 nCPM
  • renal collecting duct principal cells: 493 nCPM
  • papillary tip epithelial cells: 426 nCPM
  • distal convoluted tubule cells: 403 nCPM
  • retinal ganglion cells: 267 nCPM
  • cytotrophoblasts: 243 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 3.5 nTPM
  • thalamus: 2.7 nTPM
  • midbrain: 2.5 nTPM
  • basal ganglia: 2.3 nTPM
  • pons: 2.2 nTPM
  • white matter: 1.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.29
gnomAD pLI
0.98
gnomAD missense Z
2
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IL1RAPL2 as an antibody target. Whether an autoantibody or antibody against IL1RAPL2 could matter depends on whether native IL1RAPL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IL1RAPL2 is annotated at the cell surface, where native IL1RAPL2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IL1RAPL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IL1RAPL2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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