Seroatlas · Human Serome Atlas

IL1R2

Interleukin-1 receptor type 2

Also known as: CD121b, IL1R2_HUMAN, IL1RB

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P27930
Gene
IL1R2
Ensembl
ENSG00000115590
Chromosome
2
Canonical length
398 aa
Protein class
Cancer-related genes, CD markers, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins
Secretome location
Secreted to blood

OverviewNCBI Gene

The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. [provided by RefSeq, May 2012]

Canonical amino-acid sequenceUniProt

398 residues, UniProt reviewed canonical sequence.

>P27930|IL1R2
     1  MLRLYVLVMG VSAFTLQPAA HTGAARSCRF RGRHYKREFR LEGEPVALRC PQVPYWLWAS
    61  VSPRINLTWH KNDSARTVPG EEETRMWAQD GALWLLPALQ EDSGTYVCTT RNASYCDKMS
   121  IELRVFENTD AFLPFISYPQ ILTLSTSGVL VCPDLSEFTR DKTDVKIQWY KDSLLLDKDN
   181  EKFLSVRGTT HLLVHDVALE DAGYYRCVLT FAHEGQQYNI TRSIELRIKK KKEETIPVII
   241  SPLKTISASL GSRLTIPCKV FLGTGTPLTT MLWWTANDTH IESAYPGGRV TEGPRQEYSE
   301  NNENYIEVPL IFDPVTREDL HMDFKCVVHN TLSFQTLRTT VKEASSTFSW GIVLAPLSLA
   361  FLVLGGIWMH RRCKHRTGKA DGLTVLWPHH QDFQSYPK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IL1R2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
92 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 92 nTPM
  • bone marrow: 50 nTPM
  • esophagus: 41 nTPM
  • rectum: 41 nTPM
  • tonsil: 36 nTPM
  • appendix: 34 nTPM

Single-cell type

  • neutrophils: 17,941 nCPM
  • neutrophil progenitors: 4,229 nCPM
  • monocytes: 1,189 nCPM
  • cdc: 1,097 nCPM
  • monocyte progenitors: 737 nCPM
  • macrophages: 288 nCPM

Immune cell

  • neutrophil: 379 nTPM
  • myeloid DC: 15 nTPM
  • T-reg: 5.9 nTPM
  • classical monocyte: 4.3 nTPM
  • intermediate monocyte: 2.3 nTPM
  • total PBMC: 1.5 nTPM

Brain region

  • cerebral cortex: 15 nTPM
  • pons: 4 nTPM
  • choroid plexus: 3.5 nTPM
  • thalamus: 1.5 nTPM
  • basal ganglia: 1.4 nTPM
  • hypothalamus: 1.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.69
gnomAD pLI
0
gnomAD missense Z
-0.11
DepMap mean gene effect
-0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IL1R2 as an antibody target. Whether an autoantibody or antibody against IL1R2 could matter depends on whether native IL1R2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IL1R2 is annotated at the cell surface, where native IL1R2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IL1R2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IL1R2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...