Seroatlas · Human Serome Atlas

IL17REL

Interleukin-17 receptor E-like protein

Also known as: I17EL_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZVW7
Gene: IL17REL
Canonical length: 507 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for IL17REL in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

507 residues, UniProt reviewed canonical sequence.

>Q6ZVW7|IL17REL
     1  MLAGQALAFL GLTWGTFQSL AIPRITECGL SCSQGFACRS HRNRNIFNSF CRPRPVSMSR
    61  SVLEALTSST AMQCVPSDGC AMLLRVRASI TLHERLRGLE ACAMSLDTQE TQCQSVWVAR
   121  ASHRQQGGQQ LQVHFGCFAV SVAQHLYVTL RTIPHFCGVQ LDQRHLVEDC GEEDVGRSVP
   181  DCLAGKLSYW VDRRRKAILV QVPRASGSPD YYLRLCLKRF TCEDAGAPVR VTANSVSQAV
   241  FLPYSQELPC LCLEGWSATP DAVRIQICPF ENDTEALEVL WDTVYYHPES QTLSWEPACP
   301  VSGHVSLCWR PGPGAGCRKL QQSSQLVHRR VQYPLVDTQP QLCLKFSTSW GSWVRCPFEQ
   361  RRFPTWKMTI QPSPTKGHLR VTFFSSSPAH FQVHLCHRRK SQLPACQRTL QASPLPSASG
   421  DLAAAPAFAF LDLPREEACA PGICIQGWRT DVHFSVPQQL CNLRSSGCPS LRGRRRPRTR
   481  PRPPTAGWAW RALNRRLGGG NGETIRP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IL17REL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 4 nTPM

Expression across tissuesHPA

Tissue

tonsil: 4 nTPM
thymus: 3.2 nTPM
appendix: 2.1 nTPM
lymph node: 1.9 nTPM
stomach: 1.7 nTPM
spleen: 0.8 nTPM

Single-cell type

epicardial cells: 34 nCPM
foveolar cells: 23 nCPM
endometrial luminal cells: 23 nCPM
endometrial secretory cells: 14 nCPM
endometrial glandular cells: 14 nCPM
goblet cells: 5.9 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 2.9 nTPM
cerebral cortex: 2 nTPM
pons: 1.7 nTPM
white matter: 1.5 nTPM
midbrain: 1.4 nTPM
thalamus: 1.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.72
gnomAD pLI: 0
gnomAD missense Z: 0.29
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

interleukin-17 receptor activity

Cellular components

extracellular region

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IL17REL as an antibody target. Whether an autoantibody or antibody against IL17REL could matter depends on whether native IL17REL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IL17REL is annotated as secreted, so native IL17REL circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label IL17REL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...