Seroatlas · Human Serome Atlas

IL17D

Interleukin-17D

Also known as: FLJ30846, IL-17D, IL-27, IL17D_HUMAN, IL27

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TAD2
Gene: IL17D
Ensembl: ENSG00000172458
Chromosome: 13
Canonical length: 202 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

The protein encoded by this gene is a cytokine that shares the sequence similarity with IL17. The treatment of endothelial cells with this cytokine has been shown to stimulate the production of other cytokines including IL6, IL8 and CSF2/ GM-CSF. The increased expression of IL8 induced by this cytokine was found to be NF-kappa B-dependent. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

202 residues, UniProt reviewed canonical sequence.

>Q8TAD2|IL17D
     1  MLVAGFLLAL PPSWAAGAPR AGRRPARPRG CADRPEELLE QLYGRLAAGV LSAFHHTLQL
    61  GPREQARNAS CPAGGRPADR RFRPPTNLRS VSPWAYRISY DPARYPRYLP EAYCLCRGCL
   121  TGLFGEEDVR FRSAPVYMPT VVLRRTPACA GGRSVYTEAY VTIPVGCTCV PEPEKDADSI
   181  NSSIDKQGAK LLLGPNDAPA GP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IL17D can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 149 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 149 nTPM
amygdala: 126 nTPM
skeletal muscle: 123 nTPM
cerebral cortex: 118 nTPM
midbrain: 106 nTPM
hippocampal formation: 90 nTPM

Single-cell type

bergmann glia: 139 nCPM
astrocytes: 96 nCPM
myonuclei: 85 nCPM
late spermatids: 53 nCPM
oligodendrocyte progenitor cells: 30 nCPM
müller glia: 22 nCPM

Immune cell

NK-cell: 0.3 nTPM
memory CD8 T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

spinal cord: 141 nTPM
basal ganglia: 138 nTPM
medulla oblongata: 138 nTPM
white matter: 137 nTPM
amygdala: 123 nTPM
hypothalamus: 122 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.55
gnomAD pLI: 0.2
gnomAD missense Z: -0.26
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

extracellular space

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IL17D as an antibody target. Whether an autoantibody or antibody against IL17D could matter depends on whether native IL17D is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IL17D is annotated as secreted, so native IL17D circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label IL17D as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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