Seroatlas · Human Serome Atlas

IL17C

Interleukin-17C

Also known as: CX2, IL-17C, IL-21, IL17C_HUMAN, MGC126884, MGC138401

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P0M4
Gene: IL17C
Ensembl: ENSG00000124391
Chromosome: 16
Canonical length: 197 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

The protein encoded by this gene is a T cell-derived cytokine that shares the sequence similarity with IL17. This cytokine was reported to stimulate the release of tumor necrosis factor alpha and interleukin 1 beta from a monocytic cell line. The expression of this cytokine was found to be restricted to activated T cells. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

197 residues, UniProt reviewed canonical sequence.

>Q9P0M4|IL17C
     1  MTLLPGLLFL TWLHTCLAHH DPSLRGHPHS HGTPHCYSAE ELPLGQAPPH LLARGAKWGQ
    61  ALPVALVSSL EAASHRGRHE RPSATTQCPV LRPEEVLEAD THQRSISPWR YRVDTDEDRY
   121  PQKLAFAECL CRGCIDARTG RETAALNSVR LLQSLLVLRR RPCSRDGSGL PTPGAFAFHT
   181  EFIHVPVGCT CVLPRSV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IL17C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 1.9 nTPM

Expression across tissuesHPA

Tissue

endometrium: 1.9 nTPM
urinary bladder: 1.5 nTPM
testis: 0.4 nTPM
gallbladder: 0.3 nTPM
skin: 0.3 nTPM
bone marrow: 0.2 nTPM

Single-cell type

fallopian secretory cells: 6.6 nCPM
cholangiocytes: 4 nCPM
fallopian tube ciliated cells: 3.8 nCPM
gastric progenitor cells: 3.8 nCPM
endometrial secretory cells: 2.3 nCPM
endometrial glandular cells: 2.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 0.3 nTPM
cerebral cortex: 0.3 nTPM
basal ganglia: 0.2 nTPM
hippocampal formation: 0.2 nTPM
pons: 0.2 nTPM
amygdala: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.73
gnomAD pLI: 0
gnomAD missense Z: -0.81
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

cytokine activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IL17C as an antibody target. Whether an autoantibody or antibody against IL17C could matter depends on whether native IL17C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IL17C is annotated as secreted, so native IL17C circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label IL17C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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