Seroatlas · Human Serome Atlas

IL12RB1

Interleukin-12 receptor subunit beta-1

Also known as: CD212, I12R1_HUMAN, IL12RB

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P42701
Gene
IL12RB1
Ensembl
ENSG00000096996
Chromosome
19
Canonical length
662 aa
Protein class
CD markers, Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Plasma membrane
Secretome location
Intracellular and membrane

OverviewNCBI Gene

The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Canonical amino-acid sequenceUniProt

662 residues, UniProt reviewed canonical sequence.

>P42701|IL12RB1
     1  MEPLVTWVVP LLFLFLLSRQ GAACRTSECC FQDPPYPDAD SGSASGPRDL RCYRISSDRY
    61  ECSWQYEGPT AGVSHFLRCC LSSGRCCYFA AGSATRLQFS DQAGVSVLYT VTLWVESWAR
   121  NQTEKSPEVT LQLYNSVKYE PPLGDIKVSK LAGQLRMEWE TPDNQVGAEV QFRHRTPSSP
   181  WKLGDCGPQD DDTESCLCPL EMNVAQEFQL RRRQLGSQGS SWSKWSSPVC VPPENPPQPQ
   241  VRFSVEQLGQ DGRRRLTLKE QPTQLELPEG CQGLAPGTEV TYRLQLHMLS CPCKAKATRT
   301  LHLGKMPYLS GAAYNVAVIS SNQFGPGLNQ TWHIPADTHT EPVALNISVG TNGTTMYWPA
   361  RAQSMTYCIE WQPVGQDGGL ATCSLTAPQD PDPAGMATYS WSRESGAMGQ EKCYYITIFA
   421  SAHPEKLTLW STVLSTYHFG GNASAAGTPH HVSVKNHSLD SVSVDWAPSL LSTCPGVLKE
   481  YVVRCRDEDS KQVSEHPVQP TETQVTLSGL RAGVAYTVQV RADTAWLRGV WSQPQRFSIE
   541  VQVSDWLIFF ASLGSFLSIL LVGVLGYLGL NRAARHLCPP LPTPCASSAI EFPGGKETWQ
   601  WINPVDFQEE ASLQEALVVE MSWDKGERTE PLEKTELPEG APELALDTEL SLEDGDRCKA
   661  KM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IL12RB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
23 nTPM

Expression across tissuesHPA

Tissue

  • lymph node: 23 nTPM
  • spleen: 16 nTPM
  • appendix: 14 nTPM
  • tonsil: 13 nTPM
  • bone marrow: 8 nTPM
  • small intestine: 6.5 nTPM

Single-cell type

  • nk-cells: 30 nCPM
  • t-cells: 29 nCPM
  • neutrophils: 24 nCPM
  • kupffer cells: 20 nCPM
  • endometrial glandular cells: 16 nCPM
  • b-cells: 15 nCPM

Immune cell

  • MAIT T-cell: 63 nTPM
  • T-reg: 52 nTPM
  • gdT-cell: 50 nTPM
  • memory CD8 T-cell: 41 nTPM
  • NK-cell: 40 nTPM
  • intermediate monocyte: 34 nTPM

Brain region

  • white matter: 12 nTPM
  • medulla oblongata: 10 nTPM
  • cerebral cortex: 9.7 nTPM
  • thalamus: 9.4 nTPM
  • pons: 9.3 nTPM
  • choroid plexus: 8.7 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IL12RB1.

Disease | AllUniProt

Conditions IL12RB1 is implicated in, by any mechanism.

Disease | GeneticClinVar

76 pathogenic / likely-pathogenic of 668 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.91
gnomAD pLI
0
gnomAD missense Z
0.24
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IL12RB1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IL12RB1 as an antibody target. Whether an autoantibody or antibody against IL12RB1 could matter depends on whether native IL12RB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IL12RB1 is annotated at the cell surface, where native IL12RB1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IL12RB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IL12RB1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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