Seroatlas · Human Serome Atlas

IKBKE-AS1

Putative uncharacterized protein IKBKE-AS1

Also known as: CA147_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96MC9
Gene
IKBKE-AS1
Canonical length
270 aa

OverviewNCBI Gene

No narrative summary is available for IKBKE-AS1 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

270 residues, UniProt reviewed canonical sequence.

>Q96MC9|IKBKE-AS1
     1  MQGNNLQPPS PRPLECWSLH REAPQRTEAS RTHPSPFLAL PGSHRTANQA QVVPGLVHHP
    61  QENTQRLRIR AGLSPFPRAR LAAIGSTHGH RWVPGICLPR CLCPASCALH ACPPHCNNAE
   121  AHSWLRLGGP LQSRSVEHQQ HACGWGWVTH ATYGERGTSQ AAERQRIAHT RALSVGNCPR
   181  SHFQCEFSSI SKWSEGTGTF SPRPRAVKSG VGGQPSPHIR ITWRSCTTLT SKPCSRAITP
   241  ECVVGWSRRS RHWYSDMRTG ECQGLSPITR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IKBKE-AS1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.6

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IKBKE-AS1 as an antibody target. Whether an autoantibody or antibody against IKBKE-AS1 could matter depends on whether native IKBKE-AS1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IKBKE-AS1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IKBKE-AS1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IKBKE-AS1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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