Seroatlas · Human Serome Atlas

IGSF6

Immunoglobulin superfamily member 6

Also known as: DORA, IGSF6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95976
Gene: IGSF6
Ensembl: ENSG00000140749
Chromosome: 16
Canonical length: 241 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in cell surface receptor signaling pathway and immune response. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

241 residues, UniProt reviewed canonical sequence.

>O95976|IGSF6
     1  MGTASRSNIA RHLQTNLILF CVGAVGACTL SVTQPWYLEV DYTHEAVTIK CTFSATGCPS
    61  EQPTCLWFRY GAHQPENLCL DGCKSEADKF TVREALKENQ VSLTVNRVTS NDSAIYICGI
   121  AFPSVPEARA KQTGGGTTLV VREIKLLSKE LRSFLTALVS LLSVYVTGVC VAFILLSKSK
   181  SNPLRNKEIK EDSQKKKSAR RIFQEIAQEL YHKRHVETNQ QSEKDNNTYE NRRVLSNYER
   241  P

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGSF6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 29 nTPM

Expression across tissuesHPA

Tissue

spleen: 29 nTPM
appendix: 13 nTPM
lung: 7 nTPM
liver: 5.1 nTPM
colon: 4.8 nTPM
spinal cord: 4.6 nTPM

Single-cell type

neutrophils: 372 nCPM
kupffer cells: 231 nCPM
hofbauer cells: 188 nCPM
macrophages: 129 nCPM
monocytes: 121 nCPM
microglia: 120 nCPM

Immune cell

neutrophil: 1,230 nTPM
intermediate monocyte: 360 nTPM
classical monocyte: 306 nTPM
non-classical monocyte: 267 nTPM
myeloid DC: 236 nTPM
total PBMC: 211 nTPM

Brain region

white matter: 2.7 nTPM
medulla oblongata: 2.1 nTPM
pons: 1.9 nTPM
cerebellum: 1.6 nTPM
choroid plexus: 1.6 nTPM
midbrain: 1.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.09
gnomAD pLI: 0
gnomAD missense Z: 0.15
DepMap mean gene effect: -0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

transmembrane signaling receptor activity

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGSF6 as an antibody target. Whether an autoantibody or antibody against IGSF6 could matter depends on whether native IGSF6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGSF6 is annotated at the cell surface, where native IGSF6 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IGSF6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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