Seroatlas · Human Serome Atlas

IGSF23

Immunoglobulin superfamily member 23

Also known as: IGS23_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A1L1A6
Gene: IGSF23
Ensembl: ENSG00000216588
Chromosome: 19
Canonical length: 192 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Cell Junctions

OverviewNCBI Gene

This gene encodes a protein that has one immunoglobulin (Ig) domain and is a member of the immunoglobulin superfamily. Proteins in this superfamily are usually found on or in cell membranes and act as receptors in immune response pathways. [provided by RefSeq, Nov 2011]

Canonical amino-acid sequenceUniProt

192 residues, UniProt reviewed canonical sequence.

>A1L1A6|IGSF23
     1  MRAKPQSPLP RNPVPAWSPP TTTTDPMLEK DAAGGDFPAN LVLQLMPLKT FPAAIRGVIQ
    61  SELNYSVILQ WVVTMDPEPV LSWTFSGVPC GMGEKLFIRR LSCEQLGTYM CIATNSKKQL
   121  VSEPVTISLP KPIMQPTEAE PMEPDPTLSL SGGSAIGLLA AGILGAGALI AGMCFIIIQS
   181  LRTDRQRIGI CS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGSF23 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

liver: 23 nTPM
small intestine: 15 nTPM
duodenum: 14 nTPM
pancreas: 3.5 nTPM
testis: 1.1 nTPM
epididymis: 0.6 nTPM

Single-cell type

enterocytes: 77 nCPM
early spermatids: 49 nCPM
hepatocytes: 44 nCPM
retinal bipolar cells: 25 nCPM
late spermatids: 23 nCPM
pancreatic duct cells: 20 nCPM

Immune cell

neutrophil: 2.4 nTPM
classical monocyte: 0.5 nTPM
intermediate monocyte: 0.1 nTPM
total PBMC: 0.1 nTPM
basophil: 0 nTPM
eosinophil: 0 nTPM

Brain region

medulla oblongata: 1.3 nTPM
midbrain: 1.3 nTPM
thalamus: 1 nTPM
cerebellum: 0.7 nTPM
cerebral cortex: 0.7 nTPM
pons: 0.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.25
gnomAD pLI: 0.01
gnomAD missense Z: 0.82
DepMap mean gene effect: -0.05
DepMap dependency class: selective

OntologyGO

Biological processes

osteoclast differentiation

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGSF23 as an antibody target. Whether an autoantibody or antibody against IGSF23 could matter depends on whether native IGSF23 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGSF23 is annotated at the cell surface, where native IGSF23 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IGSF23 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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