IGSF21
Immunoglobulin superfamily member 21
Also known as: IGS21_HUMAN, MGC15730, RP11-121A23.1
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96ID5
- Gene
- IGSF21
- Ensembl
- ENSG00000117154
- Chromosome
- 1
- Canonical length
- 467 aa
- Protein class
- Predicted intracellular proteins
- Secretome location
- Intracellular and membrane
OverviewNCBI Gene
This gene encodes a protein which has two immunoglobulin (Ig) domains and is a member of the immunoglobulin superfamily. Proteins in this superfamily are usually found on or in cell membranes and act as receptors in immune response pathways. [provided by RefSeq, Sep 2011]
Canonical amino-acid sequenceUniProt
467 residues, UniProt reviewed canonical sequence.
>Q96ID5|IGSF21
1 MRTAPSLRRC VCLLLAAILD LARGYLTVNI EPLPPVVAGD AVTLKCNFKT DGRMREIVWY
61 RVTDGGTIKQ KIFTFDAMFS TNYSHMENYR KREDLVYQST VRLPEVRISD NGPYECHVGI
121 YDRATREKVV LASGNIFLNV MAPPTSIEVV AADTPAPFSR YQAQNFTLVC IVSGGKPAPM
181 VYFKRDGEPI DAVPLSEPPA ASSGPLQDSR PFRSLLHRDL DDTKMQKSLS LLDAENRGGR
241 PYTERPSRGL TPDPNILLQP TTENIPETVV SREFPRWVHS AEPTYFLRHS RTPSSDGTVE
301 VRALLTWTLN PQIDNEALFS CEVKHPALSM PMQAEVTLVA PKGPKIVMTP SRARVGDTVR
361 ILVHGFQNEV FPEPMFTWTR VGSRLLDGSA EFDGKELVLE RVPAELNGSM YRCTAQNPLG
421 STDTHTRLIV FENPNIPRGT EDSNGSIGPT GARLTLVLAL TVILELTLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGSF21 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.43
- Highest tissue expression
- 97 nTPM
Expression across tissuesHPA
Tissue
- cerebellum: 97 nTPM
- cerebral cortex: 59 nTPM
- hippocampal formation: 43 nTPM
- amygdala: 30 nTPM
- midbrain: 20 nTPM
- hypothalamus: 20 nTPM
Single-cell type
- retinal bipolar cells: 333 nCPM
- microglia: 313 nCPM
- oligodendrocyte progenitor cells: 257 nCPM
- tuft cells: 196 nCPM
- brain excitatory neurons: 122 nCPM
- macrophages: 120 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebellum: 78 nTPM
- cerebral cortex: 78 nTPM
- white matter: 60 nTPM
- basal ganglia: 55 nTPM
- hippocampal formation: 53 nTPM
- pons: 48 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.53
- gnomAD pLI
- 0.21
- gnomAD missense Z
- 0.32
- DepMap mean gene effect
- -0.02
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGSF21 as an antibody target. Whether an autoantibody or antibody against IGSF21 could matter depends on whether native IGSF21 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGSF21 is annotated at the cell surface, where native IGSF21 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label IGSF21 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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