Seroatlas · Human Serome Atlas

IGSF11

Immunoglobulin superfamily member 11

Also known as: BT-IgSF, CT119, IGS11_HUMAN, Igsf13, MGC35227, VSIG3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5DX21
Gene: IGSF11
Ensembl: ENSG00000144847
Chromosome: 3
Canonical length: 431 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Cell Junctions,Cytosol

OverviewNCBI Gene

IGSF11 is an immunoglobulin (Ig) superfamily member that is preferentially expressed in brain and testis. It shares significant homology with coxsackievirus and adenovirus receptor (CXADR; MIM 602621) and endothelial cell-selective adhesion molecule (ESAM).[supplied by OMIM, Apr 2005]

Canonical amino-acid sequenceUniProt

431 residues, UniProt reviewed canonical sequence.

>Q5DX21|IGSF11
     1  MTSQRSPLAP LLLLSLHGVA ASLEVSESPG SIQVARGQPA VLPCTFTTSA ALINLNVIWM
    61  VTPLSNANQP EQVILYQGGQ MFDGAPRFHG RVGFTGTMPA TNVSIFINNT QLSDTGTYQC
   121  LVNNLPDIGG RNIGVTGLTV LVPPSAPHCQ IQGSQDIGSD VILLCSSEEG IPRPTYLWEK
   181  LDNTLKLPPT ATQDQVQGTV TIRNISALSS GLYQCVASNA IGTSTCLLDL QVISPQPRNI
   241  GLIAGAIGTG AVIIIFCIAL ILGAFFYWRS KNKEEEEEEI PNEIREDDLP PKCSSAKAFH
   301  TEISSSDNNT LTSSNAYNSR YWSNNPKVHR NTESVSHFSD LGQSFSFHSG NANIPSIYAN
   361  GTHLVPGQHK TLVVTANRGS SPQVMSRSNG SVSRKPRPPH THSYTISHAT LERIGAVPVM
   421  VPAQSRAGSL V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGSF11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 47 nTPM

Expression across tissuesHPA

Tissue

retina: 47 nTPM
testis: 33 nTPM
spinal cord: 28 nTPM
basal ganglia: 17 nTPM
cerebral cortex: 17 nTPM
midbrain: 15 nTPM

Single-cell type

early spermatids: 633 nCPM
late spermatids: 534 nCPM
cone photoreceptor cells: 484 nCPM
oligodendrocytes: 450 nCPM
astrocytes: 293 nCPM
late primary spermatocytes: 280 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 103 nTPM
basal ganglia: 80 nTPM
medulla oblongata: 75 nTPM
midbrain: 69 nTPM
cerebellum: 67 nTPM
thalamus: 64 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.79
gnomAD pLI: 0
gnomAD missense Z: 1.21
DepMap mean gene effect: -0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

ionotropic glutamate receptor binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGSF11 as an antibody target. Whether an autoantibody or antibody against IGSF11 could matter depends on whether native IGSF11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGSF11 is annotated at the cell surface, where native IGSF11 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IGSF11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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