IGLV9-49
Immunoglobulin lambda variable 9-49
Also known as: LV949_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A0B4J1Y8
- Gene
- IGLV9-49
- Ensembl
- ENSG00000223350
- Chromosome
- 22
- Canonical length
- 123 aa
- Protein class
- Immunoglobulin genes, Predicted secreted proteins
- Secretome location
- Immunoglobulin genes
OverviewNCBI Gene
Predicted to be involved in immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
123 residues, UniProt reviewed canonical sequence.
>A0A0B4J1Y8|IGLV9-49
1 MAWAPLLLTL LSLLTGSLSQ PVLTQPPSAS ASLGASVTLT CTLSSGYSNY KVDWYQQRPG
61 KGPRFVMRVG TGGIVGSKGD GIPDRFSVLG SGLNRYLTIK NIQEEDESDY HCGADHGSGS
121 NFVLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGLV9-49 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 118 nTPM
Expression across tissuesHPA
Tissue
- adrenal gland: 118 nTPM
- lymph node: 111 nTPM
- tonsil: 92 nTPM
- spleen: 62 nTPM
- stomach: 44 nTPM
- lung: 41 nTPM
Single-cell type
- tuft cells: 12 nCPM
- plasma cells: 4 nCPM
- mucous neck cells: 0.8 nCPM
- b-cells: 0.2 nCPM
- erythrocytes: 0.2 nCPM
- early primary spermatocytes: 0.1 nCPM
Immune cell
- naive B-cell: 89 nTPM
- memory B-cell: 71 nTPM
- total PBMC: 6.2 nTPM
- myeloid DC: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
Brain region
- cerebral cortex: 1.2 nTPM
- pons: 0.7 nTPM
- hippocampal formation: 0.5 nTPM
- medulla oblongata: 0.5 nTPM
- cerebellum: 0.4 nTPM
- white matter: 0.4 nTPM
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGLV9-49 as an antibody target. Whether an autoantibody or antibody against IGLV9-49 could matter depends on whether native IGLV9-49 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGLV9-49 is annotated at the cell surface, where native IGLV9-49 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label IGLV9-49 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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