Seroatlas · Human Serome Atlas

IGLV8-61

Immunoglobulin lambda variable 8-61

Also known as: LV861_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A075B6I0
Gene
IGLV8-61
Ensembl
ENSG00000211638
Chromosome
22
Canonical length
122 aa
Protein class
Immunoglobulin genes, Predicted secreted proteins
Secretome location
Immunoglobulin genes

OverviewNCBI Gene

Predicted to be involved in immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

122 residues, UniProt reviewed canonical sequence.

>A0A075B6I0|IGLV8-61
     1  MSVPTMAWMM LLLGLLAYGS GVDSQTVVTQ EPSFSVSPGG TVTLTCGLSS GSVSTSYYPS
    61  WYQQTPGQAP RTLIYSTNTR SSGVPDRFSG SILGNKAALT ITGAQADDES DYYCVLYMGS
   121  GI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGLV8-61 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Highest tissue expression
916 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 916 nTPM
  • duodenum: 756 nTPM
  • spleen: 255 nTPM
  • lymph node: 241 nTPM
  • urinary bladder: 232 nTPM
  • colon: 187 nTPM

Single-cell type

  • plasma cells: 13 nCPM
  • foveolar cells: 1.5 nCPM
  • cholangiocytes: 1.3 nCPM
  • gastric chief cells: 1.1 nCPM
  • kupffer cells: 1 nCPM
  • melanocytes: 0.4 nCPM

Immune cell

  • naive B-cell: 534 nTPM
  • memory B-cell: 259 nTPM
  • total PBMC: 33 nTPM
  • classical monocyte: 0.6 nTPM
  • myeloid DC: 0.4 nTPM
  • non-classical monocyte: 0.4 nTPM

Brain region

  • cerebral cortex: 3.3 nTPM
  • choroid plexus: 1.7 nTPM
  • white matter: 1.6 nTPM
  • pons: 1.3 nTPM
  • spinal cord: 1.3 nTPM
  • medulla oblongata: 0.4 nTPM

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGLV8-61 as an antibody target. Whether an autoantibody or antibody against IGLV8-61 could matter depends on whether native IGLV8-61 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGLV8-61 is annotated at the cell surface, where native IGLV8-61 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IGLV8-61 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IGLV8-61. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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