IGLV7-46
Immunoglobulin lambda variable 7-46
Also known as: LV746_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A075B6I9
- Gene
- IGLV7-46
- Ensembl
- ENSG00000211649
- Chromosome
- 22
- Canonical length
- 117 aa
- Protein class
- Immunoglobulin genes, Predicted secreted proteins
- Secretome location
- Immunoglobulin genes
OverviewNCBI Gene
Predicted to be involved in immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
117 residues, UniProt reviewed canonical sequence.
>A0A075B6I9|IGLV7-46
1 MAWTPLFLFL LTCCPGSNSQ AVVTQEPSLT VSPGGTVTLT CGSSTGAVTS GHYPYWFQQK
61 PGQAPRTLIY DTSNKHSWTP ARFSGSLLGG KAALTLLGAQ PEDEAEYYCL LSYSGARLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGLV7-46 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 429 nTPM
Expression across tissuesHPA
Tissue
- tonsil: 429 nTPM
- urinary bladder: 417 nTPM
- colon: 374 nTPM
- rectum: 279 nTPM
- stomach: 236 nTPM
- spleen: 226 nTPM
Single-cell type
- plasma cells: 19 nCPM
- gastric chief cells: 3.3 nCPM
- foveolar cells: 1.9 nCPM
- parietal cells: 1.8 nCPM
- neuroendocrine cells: 1.4 nCPM
- kupffer cells: 1 nCPM
Immune cell
- memory B-cell: 185 nTPM
- naive B-cell: 83 nTPM
- total PBMC: 15 nTPM
- naive CD4 T-cell: 0.3 nTPM
- neutrophil: 0.2 nTPM
- basophil: 0.1 nTPM
Brain region
- hypothalamus: 3.1 nTPM
- cerebral cortex: 1 nTPM
- medulla oblongata: 0.7 nTPM
- white matter: 0.7 nTPM
- basal ganglia: 0.5 nTPM
- pons: 0.5 nTPM
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGLV7-46 as an antibody target. Whether an autoantibody or antibody against IGLV7-46 could matter depends on whether native IGLV7-46 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGLV7-46 is annotated at the cell surface, where native IGLV7-46 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label IGLV7-46 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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