IGLV7-43
Immunoglobulin lambda variable 7-43
Also known as: LV743_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P04211
- Gene
- IGLV7-43
- Ensembl
- ENSG00000211652
- Chromosome
- 22
- Canonical length
- 117 aa
- Protein class
- Immunoglobulin genes, Predicted secreted proteins
- Secretome location
- Immunoglobulin genes
OverviewNCBI Gene
Predicted to enable antigen binding activity. Predicted to be involved in immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
117 residues, UniProt reviewed canonical sequence.
>P04211|IGLV7-43
1 MAWTPLFLFL LTCCPGSNSQ TVVTQEPSLT VSPGGTVTLT CASSTGAVTS GYYPNWFQQK
61 PGQAPRALIY STSNKHSWTP ARFSGSLLGG KAALTLSGVQ PEDEAEYYCL LYYGGAQLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGLV7-43 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 223 nTPM
Expression across tissuesHPA
Tissue
- tonsil: 223 nTPM
- spleen: 155 nTPM
- colon: 151 nTPM
- duodenum: 125 nTPM
- rectum: 121 nTPM
- stomach: 109 nTPM
Single-cell type
- plasma cells: 1.4 nCPM
- gastric chief cells: 1.1 nCPM
- neuroendocrine cells: 0.9 nCPM
- mucous neck cells: 0.4 nCPM
- b-cells: 0.1 nCPM
- adipocytes: 0 nCPM
Immune cell
- memory B-cell: 133 nTPM
- naive B-cell: 55 nTPM
- total PBMC: 10 nTPM
- neutrophil: 0.2 nTPM
- classical monocyte: 0.1 nTPM
- basophil: 0 nTPM
Brain region
- basal ganglia: 0.3 nTPM
- cerebral cortex: 0.3 nTPM
- hypothalamus: 0.2 nTPM
- pons: 0.2 nTPM
- medulla oblongata: 0.1 nTPM
- thalamus: 0.1 nTPM
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGLV7-43 as an antibody target. Whether an autoantibody or antibody against IGLV7-43 could matter depends on whether native IGLV7-43 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGLV7-43 is annotated at the cell surface, where native IGLV7-43 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label IGLV7-43 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...