Seroatlas · Human Serome Atlas

IGLV6-57

Immunoglobulin lambda variable 6-57

Also known as: LV657_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P01721
Gene
IGLV6-57
Ensembl
ENSG00000211640
Chromosome
22
Canonical length
117 aa
Protein class
Immunoglobulin genes, Predicted secreted proteins
Secretome location
Immunoglobulin genes

OverviewNCBI Gene

Predicted to enable antigen binding activity. Predicted to be involved in immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

117 residues, UniProt reviewed canonical sequence.

>P01721|IGLV6-57
     1  MAWAPLLLTL LAHCTGSWAN FMLTQPHSVS ESPGKTVTIS CTGSSGSIAS NYVQWYQQRP
    61  GSAPTTVIYE DNQRPSGVPD RFSGSIDSSS NSASLTISGL KTEDEADYYC QSYDSSN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGLV6-57 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Highest tissue expression
1,687 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 1,687 nTPM
  • urinary bladder: 634 nTPM
  • colon: 453 nTPM
  • stomach: 412 nTPM
  • duodenum: 330 nTPM
  • rectum: 297 nTPM

Single-cell type

  • plasma cells: 237 nCPM
  • parietal cells: 5.3 nCPM
  • mucous neck cells: 3.5 nCPM
  • gastric chief cells: 3.3 nCPM
  • foveolar cells: 1.5 nCPM
  • mast cells: 1.2 nCPM

Immune cell

  • memory B-cell: 356 nTPM
  • naive B-cell: 294 nTPM
  • neutrophil: 28 nTPM
  • total PBMC: 28 nTPM
  • MAIT T-cell: 2.3 nTPM
  • plasmacytoid DC: 1.2 nTPM

Brain region

  • pons: 1.3 nTPM
  • cerebral cortex: 1.2 nTPM
  • medulla oblongata: 0.8 nTPM
  • choroid plexus: 0.7 nTPM
  • white matter: 0.5 nTPM
  • basal ganglia: 0.3 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGLV6-57 as an antibody target. Whether an autoantibody or antibody against IGLV6-57 could matter depends on whether native IGLV6-57 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGLV6-57 is annotated at the cell surface, where native IGLV6-57 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IGLV6-57 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IGLV6-57. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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