Seroatlas · Human Serome Atlas

IGLV5-52

Immunoglobulin lambda variable 5-52

Also known as: LV552_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A0A0MRZ9
Gene
IGLV5-52
Ensembl
ENSG00000211643
Chromosome
22
Canonical length
124 aa
Protein class
Immunoglobulin genes, Predicted secreted proteins
Secretome location
Immunoglobulin genes

OverviewNCBI Gene

Predicted to be involved in immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

124 residues, UniProt reviewed canonical sequence.

>A0A0A0MRZ9|IGLV5-52
     1  MAWTLLLLVL LSHCTGSLSQ PVLTQPSSHS ASSGASVRLT CMLSSGFSVG DFWIRWYQQK
    61  PGNPPRYLLY YHSDSNKGQG SGVPSRFSGS NDASANAGIL RISGLQPEDE ADYYCGTWHS
   121  NSKT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGLV5-52 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Highest tissue expression
50 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 50 nTPM
  • epididymis: 42 nTPM
  • lymph node: 41 nTPM
  • skin: 35 nTPM
  • urinary bladder: 29 nTPM
  • stomach: 28 nTPM

Single-cell type

  • papillary tip epithelial cells: 0.4 nCPM
  • podocytes: 0.3 nCPM
  • renal connecting tubule cells: 0.3 nCPM
  • distal convoluted tubule cells: 0.2 nCPM
  • loop of henle epithelial cells: 0.1 nCPM
  • proximal tubule cells: 0.1 nCPM

Immune cell

  • memory B-cell: 12 nTPM
  • naive B-cell: 10 nTPM
  • total PBMC: 3.1 nTPM
  • eosinophil: 1.9 nTPM
  • myeloid DC: 1.5 nTPM
  • plasmacytoid DC: 1.4 nTPM

Brain region

  • cerebellum: 41 nTPM
  • white matter: 35 nTPM
  • choroid plexus: 34 nTPM
  • cerebral cortex: 34 nTPM
  • hippocampal formation: 31 nTPM
  • basal ganglia: 31 nTPM

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGLV5-52 as an antibody target. Whether an autoantibody or antibody against IGLV5-52 could matter depends on whether native IGLV5-52 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGLV5-52 is annotated at the cell surface, where native IGLV5-52 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IGLV5-52 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IGLV5-52. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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