IGLV5-45
Immunoglobulin lambda variable 5-45
Also known as: LV545_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A087WSX0
- Gene
- IGLV5-45
- Ensembl
- ENSG00000211650
- Chromosome
- 22
- Canonical length
- 123 aa
- Protein class
- Immunoglobulin genes, Predicted secreted proteins
- Secretome location
- Immunoglobulin genes
OverviewNCBI Gene
Predicted to be involved in immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
123 residues, UniProt reviewed canonical sequence.
>A0A087WSX0|IGLV5-45
1 MAWTPLLLLF LSHCTGSLSQ AVLTQPSSLS ASPGASASLT CTLCSGINVG TYRIYWYQQK
61 PGSPPQYLLR YKSDSDKQQG SGVPSRFSGS KDASANAGIL LISGLQSEDE ADYYCMIWHS
121 SASLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGLV5-45 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 91 nTPM
Expression across tissuesHPA
Tissue
- spleen: 91 nTPM
- salivary gland: 47 nTPM
- colon: 41 nTPM
- small intestine: 39 nTPM
- esophagus: 38 nTPM
- stomach: 13 nTPM
Single-cell type
- plasma cells: 3.9 nCPM
- gastric progenitor cells: 1.3 nCPM
- mucous neck cells: 0.8 nCPM
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
Immune cell
- memory B-cell: 1.2 nTPM
- naive B-cell: 1.1 nTPM
- classical monocyte: 0.1 nTPM
- basophil: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
Brain region
- white matter: 0.4 nTPM
- cerebral cortex: 0.2 nTPM
- medulla oblongata: 0.2 nTPM
- pons: 0.2 nTPM
- thalamus: 0.1 nTPM
- amygdala: 0 nTPM
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGLV5-45 as an antibody target. Whether an autoantibody or antibody against IGLV5-45 could matter depends on whether native IGLV5-45 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGLV5-45 is annotated at the cell surface, where native IGLV5-45 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label IGLV5-45 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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