IGLV5-37
Immunoglobulin lambda variable 5-37
Also known as: LV537_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A075B6J1
- Gene
- IGLV5-37
- Ensembl
- ENSG00000211654
- Chromosome
- 22
- Canonical length
- 123 aa
- Protein class
- Immunoglobulin genes, Predicted secreted proteins
- Secretome location
- Immunoglobulin genes
OverviewNCBI Gene
Predicted to be involved in immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
123 residues, UniProt reviewed canonical sequence.
>A0A075B6J1|IGLV5-37
1 MAWTPLLLLL LSHCTGSLSQ PVLTQPPSSS ASPGESARLT CTLPSDINVG SYNIYWYQQK
61 PGSPPRYLLY YYSDSDKGQG SGVPSRFSGS KDASANTGIL LISGLQSEDE ADYYCMIWPS
121 NASLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGLV5-37 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 39 nTPM
Expression across tissuesHPA
Tissue
- tonsil: 39 nTPM
- gallbladder: 23 nTPM
- spleen: 22 nTPM
- stomach: 16 nTPM
- salivary gland: 11 nTPM
- colon: 9.8 nTPM
Single-cell type
- plasma cells: 0.1 nCPM
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
- alveolar cells type 1: 0 nCPM
- alveolar cells type 2: 0 nCPM
Immune cell
- naive B-cell: 7 nTPM
- memory B-cell: 6.2 nTPM
- total PBMC: 0.5 nTPM
- neutrophil: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
Brain region
- hypothalamus: 0.3 nTPM
- basal ganglia: 0.2 nTPM
- cerebral cortex: 0.2 nTPM
- white matter: 0.2 nTPM
- amygdala: 0.1 nTPM
- hippocampal formation: 0.1 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about IGLV5-37.
Disease | ImmuneIEDB
Conditions an epitope on IGLV5-37 was assayed in.
- skin melanoma T cell
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGLV5-37 as an antibody target. Whether an autoantibody or antibody against IGLV5-37 could matter depends on whether native IGLV5-37 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGLV5-37 is annotated at the cell surface, where native IGLV5-37 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label IGLV5-37 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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