IGLV4-69
Immunoglobulin lambda variable 4-69
Also known as: LV469_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A075B6H9
- Gene
- IGLV4-69
- Ensembl
- ENSG00000211637
- Chromosome
- 22
- Canonical length
- 119 aa
- Protein class
- Immunoglobulin genes, Predicted secreted proteins
- Secretome location
- Immunoglobulin genes
OverviewNCBI Gene
Predicted to be involved in immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
119 residues, UniProt reviewed canonical sequence.
>A0A075B6H9|IGLV4-69
1 MAWTPLLFLT LLLHCTGSLS QLVLTQSPSA SASLGASVKL TCTLSSGHSS YAIAWHQQQP
61 EKGPRYLMKL NSDGSHSKGD GIPDRFSGSS SGAERYLTIS SLQSEDEADY YCQTWGTGILocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGLV4-69 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 431 nTPM
Expression across tissuesHPA
Tissue
- tonsil: 431 nTPM
- lymph node: 422 nTPM
- duodenum: 404 nTPM
- colon: 305 nTPM
- spleen: 279 nTPM
- stomach: 269 nTPM
Single-cell type
- plasma cells: 37 nCPM
- gastric chief cells: 9.8 nCPM
- foveolar cells: 2.3 nCPM
- parietal cells: 1.8 nCPM
- erythrocytes: 1.6 nCPM
- b-cells: 0.8 nCPM
Immune cell
- memory B-cell: 333 nTPM
- naive B-cell: 225 nTPM
- total PBMC: 32 nTPM
- neutrophil: 0.9 nTPM
- basophil: 0.3 nTPM
- memory CD4 T-cell: 0.2 nTPM
Brain region
- medulla oblongata: 2.1 nTPM
- thalamus: 0.5 nTPM
- pons: 0.4 nTPM
- cerebral cortex: 0.3 nTPM
- white matter: 0.3 nTPM
- cerebellum: 0.2 nTPM
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGLV4-69 as an antibody target. Whether an autoantibody or antibody against IGLV4-69 could matter depends on whether native IGLV4-69 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGLV4-69 is annotated at the cell surface, where native IGLV4-69 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label IGLV4-69 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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