IGLV4-60
Immunoglobulin lambda variable 4-60
Also known as: LV460_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A075B6I1
- Gene
- IGLV4-60
- Ensembl
- ENSG00000211639
- Chromosome
- 22
- Canonical length
- 120 aa
- Protein class
- Immunoglobulin genes, Predicted secreted proteins
- Secretome location
- Immunoglobulin genes
OverviewNCBI Gene
Predicted to be involved in immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
120 residues, UniProt reviewed canonical sequence.
>A0A075B6I1|IGLV4-60
1 MAWTPLLLLF PLLLHCTGSL SQPVLTQSSS ASASLGSSVK LTCTLSSGHS SYIIAWHQQQ
61 PGKAPRYLMK LEGSGSYNKG SGVPDRFSGS SSGADRYLTI SNLQFEDEAD YYCETWDSNTLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGLV4-60 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 181 nTPM
Expression across tissuesHPA
Tissue
- duodenum: 181 nTPM
- urinary bladder: 174 nTPM
- lymph node: 109 nTPM
- tonsil: 104 nTPM
- small intestine: 82 nTPM
- spleen: 72 nTPM
Single-cell type
- plasma cells: 5.5 nCPM
- mucous neck cells: 0.4 nCPM
- b-cells: 0.2 nCPM
- undifferentiated spermatogonia: 0.1 nCPM
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
Immune cell
- memory B-cell: 80 nTPM
- naive B-cell: 49 nTPM
- total PBMC: 3.9 nTPM
- neutrophil: 0.8 nTPM
- T-reg: 0.4 nTPM
- memory CD4 T-cell: 0.1 nTPM
Brain region
- cerebral cortex: 0.4 nTPM
- choroid plexus: 0.4 nTPM
- medulla oblongata: 0.2 nTPM
- pons: 0.2 nTPM
- basal ganglia: 0.1 nTPM
- hippocampal formation: 0.1 nTPM
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGLV4-60 as an antibody target. Whether an autoantibody or antibody against IGLV4-60 could matter depends on whether native IGLV4-60 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGLV4-60 is annotated at the cell surface, where native IGLV4-60 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label IGLV4-60 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...