IGLV4-3
Immunoglobulin lambda variable 4-3
Also known as: LV403_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A075B6K6
- Gene
- IGLV4-3
- Ensembl
- ENSG00000211672
- Chromosome
- 22
- Canonical length
- 122 aa
- Protein class
- Immunoglobulin genes, Predicted secreted proteins
- Secretome location
- Immunoglobulin genes
OverviewNCBI Gene
Predicted to be involved in immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
122 residues, UniProt reviewed canonical sequence.
>A0A075B6K6|IGLV4-3
1 MAWVSFYLLP FIFSTGLCAL PVLTQPPSAS ALLGASIKLT CTLSSEHSTY TIEWYQQRPG
61 RSPQYIMKVK SDGSHSKGDG IPDRFMGSSS GADRYLTFSN LQSDDEAEYH CGESHTIDGQ
121 VGLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGLV4-3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 27 nTPM
Expression across tissuesHPA
Tissue
- stomach: 27 nTPM
- tonsil: 15 nTPM
- lymph node: 9.4 nTPM
- spleen: 5.2 nTPM
- colon: 4.8 nTPM
- duodenum: 4.2 nTPM
Single-cell type
- plasma cells: 0.5 nCPM
- b-cells: 0.1 nCPM
- adipocytes: 0 nCPM
- adrenal cortex cells: 0 nCPM
- adrenal medulla cells: 0 nCPM
- alveolar cells type 1: 0 nCPM
Immune cell
- memory B-cell: 12 nTPM
- naive B-cell: 7.8 nTPM
- total PBMC: 0.7 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
Brain region
- medulla oblongata: 1.1 nTPM
- pons: 0.3 nTPM
- basal ganglia: 0.1 nTPM
- cerebral cortex: 0.1 nTPM
- midbrain: 0.1 nTPM
- thalamus: 0.1 nTPM
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGLV4-3 as an antibody target. Whether an autoantibody or antibody against IGLV4-3 could matter depends on whether native IGLV4-3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGLV4-3 is annotated at the cell surface, where native IGLV4-3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label IGLV4-3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
Loading the interactive Seroatlas protein explorer...