IGLV3-9
Immunoglobulin lambda variable 3-9
Also known as: LV39_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A0A075B6K5
- Gene
- IGLV3-9
- Ensembl
- ENSG00000211670
- Chromosome
- 22
- Canonical length
- 115 aa
- Protein class
- Immunoglobulin genes, Predicted secreted proteins
- Secretome location
- Immunoglobulin genes
OverviewNCBI Gene
Predicted to be involved in immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
115 residues, UniProt reviewed canonical sequence.
>A0A075B6K5|IGLV3-9
1 MAWTALLLSL LAHFTGSVAS YELTQPLSVS VALGQTARIT CGGNNIGSKN VHWYQQKPGQ
61 APVLVIYRDS NRPSGIPERF SGSNSGNTAT LTISRAQAGD EADYYCQVWD SSTAHLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGLV3-9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 293 nTPM
Expression across tissuesHPA
Tissue
- tonsil: 293 nTPM
- lymph node: 131 nTPM
- stomach: 110 nTPM
- colon: 81 nTPM
- appendix: 80 nTPM
- urinary bladder: 68 nTPM
Single-cell type
- plasma cells: 7.7 nCPM
- platelets: 2.8 nCPM
- mucous neck cells: 1.2 nCPM
- foveolar cells: 0.9 nCPM
- neuroendocrine cells: 0.5 nCPM
- late spermatids: 0.3 nCPM
Immune cell
- naive B-cell: 170 nTPM
- memory B-cell: 65 nTPM
- total PBMC: 6.5 nTPM
- MAIT T-cell: 2.2 nTPM
- naive CD8 T-cell: 1.8 nTPM
- memory CD8 T-cell: 1.4 nTPM
Brain region
- medulla oblongata: 1.6 nTPM
- amygdala: 0.3 nTPM
- choroid plexus: 0.3 nTPM
- pons: 0.3 nTPM
- cerebral cortex: 0.2 nTPM
- thalamus: 0.2 nTPM
OntologyGO
Biological processes
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGLV3-9 as an antibody target. Whether an autoantibody or antibody against IGLV3-9 could matter depends on whether native IGLV3-9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGLV3-9 is annotated at the cell surface, where native IGLV3-9 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label IGLV3-9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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