Seroatlas · Human Serome Atlas

IGLV3-32

Probable non-functional immunoglobulin lambda variable 3-32

Also known as: LV332_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A0A0MS00
Gene
IGLV3-32
Ensembl
ENSG00000211657
Chromosome
22
Canonical length
114 aa
Protein class
Immunoglobulin genes, Predicted secreted proteins
Secretome location
Immunoglobulin genes

OverviewNCBI Gene

Predicted to be involved in immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

114 residues, UniProt reviewed canonical sequence.

>A0A0A0MS00|IGLV3-32
     1  MAWTPPLLVL TLCTGSVISS GPTQVPAVSV ALGQMARITC QGDSMEGSYE HWYQQKPGQA
    61  PVLVIYDSSD RPSRIPERFS GSKSGNTTTL TITGAQAEDE ADYYYQLIDN HATQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGLV3-32 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Highest tissue expression
1.3 nTPM

Expression across tissuesHPA

Tissue

  • urinary bladder: 1.3 nTPM
  • tonsil: 0.7 nTPM
  • bone marrow: 0.6 nTPM
  • duodenum: 0.5 nTPM
  • stomach: 0.4 nTPM
  • breast: 0.3 nTPM

Single-cell type

  • adipocytes: 0 nCPM
  • adrenal cortex cells: 0 nCPM
  • adrenal medulla cells: 0 nCPM
  • alveolar cells type 1: 0 nCPM
  • alveolar cells type 2: 0 nCPM
  • astrocytes: 0 nCPM

Immune cell

  • memory B-cell: 0.1 nTPM
  • naive B-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM
  • hippocampal formation: 0 nTPM

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGLV3-32 as an antibody target. Whether an autoantibody or antibody against IGLV3-32 could matter depends on whether native IGLV3-32 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGLV3-32 is annotated at the cell surface, where native IGLV3-32 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IGLV3-32 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IGLV3-32. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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