IGLV3-27
Immunoglobulin lambda variable 3-27
Also known as: LV327_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P01718
- Gene
- IGLV3-27
- Ensembl
- ENSG00000211658
- Chromosome
- 22
- Canonical length
- 113 aa
- Protein class
- Immunoglobulin genes, Predicted secreted proteins
- Secretome location
- Immunoglobulin genes
OverviewNCBI Gene
Predicted to enable antigen binding activity. Predicted to be involved in immune response. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
113 residues, UniProt reviewed canonical sequence.
>P01718|IGLV3-27
1 MAWIPLLLPL LILCTVSVAS YELTQPSSVS VSPGQTARIT CSGDVLAKKY ARWFQQKPGQ
61 APVLVIYKDS ERPSGIPERF SGSSSGTTVT LTISGAQVED EADYYCYSAA DNNLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGLV3-27 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 375 nTPM
Expression across tissuesHPA
Tissue
- tonsil: 375 nTPM
- spleen: 94 nTPM
- lymph node: 60 nTPM
- stomach: 56 nTPM
- colon: 53 nTPM
- thymus: 44 nTPM
Single-cell type
- plasma cells: 5.3 nCPM
- foveolar cells: 0.6 nCPM
- mucous neck cells: 0.4 nCPM
- b-cells: 0.1 nCPM
- hepatocytes: 0.1 nCPM
- adipocytes: 0 nCPM
Immune cell
- naive B-cell: 371 nTPM
- memory B-cell: 195 nTPM
- total PBMC: 12 nTPM
- classical monocyte: 0.3 nTPM
- myeloid DC: 0.3 nTPM
- memory CD4 T-cell: 0.2 nTPM
Brain region
- cerebral cortex: 1 nTPM
- medulla oblongata: 0.9 nTPM
- amygdala: 0.4 nTPM
- white matter: 0.4 nTPM
- choroid plexus: 0.3 nTPM
- pons: 0.3 nTPM
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGLV3-27 as an antibody target. Whether an autoantibody or antibody against IGLV3-27 could matter depends on whether native IGLV3-27 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGLV3-27 is annotated at the cell surface, where native IGLV3-27 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label IGLV3-27 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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